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Title: Forgotten Antibiotics: An Inventory in Europe, the United States, Canada, and Australia
Authors: Pulcini, Celine
Bush, Karen
Craig, William A.
Frimodt-Moller, Niels
Grayson, M. Lindsay
Mouton, Johan W.
Turnidge, John
Harbarth, Stephan
Issue Date: 2012
Source: CLINICAL INFECTIOUS DISEASES, 54(2), p. 268-274
Abstract: In view of the alarming spread of antimicrobial resistance in the absence of new antibiotics, this study aimed at assessing the availability of potentially useful older antibiotics. A survey was performed in 38 countries among experts including hospital pharmacists, microbiologists, and infectious disease specialists in Europe, the United States, Canada, and Australia. An international expert panel selected systemic antibacterial drugs for their potential to treat infections caused by resistant bacteria or their unique value for specific criteria. Twenty-two of the 33 selected antibiotics were available in fewer than 20 of 38 countries. Economic motives were the major cause for discontinuation of marketing of these antibiotics. Fourteen of 33 antibiotics are potentially active against either resistant Gram-positive or Gram-negative bacteria. Urgent measures are then needed to ensure better availability of these antibiotics on a global scale.
Notes: [Pulcini, Celine] Ctr Hosp Univ Nice, Serv Infectiol, F-06202 Nice 3, France. [Pulcini, Celine] Univ Nice Sophia Antipolis, Fac Med, Nice, France. [Bush, Karen] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA. [Craig, William A.] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53706 USA. [Frimodt-Moller, Niels] Hvidovre Univ Hosp, Dept Clin Microbiol, Copenhagen, Denmark. [Grayson, M. Lindsay] Univ Melbourne, Dept Med, Melbourne, Vic 3010, Australia. [Mouton, Johan W.] Radboud Univ Nijmegen, Dept Med Microbiol, Med Ctr, Nijmegen, Netherlands. [Mouton, Johan W.; Gyssens, Inge C.] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands. [Turnidge, John] Univ Adelaide, SA Pathol, Adelaide, SA 5005, Australia. [Gyssens, Inge C.] Radboud Univ Nijmegen, Med Ctr, Dept Med, Nijmegen, Netherlands. [Harbarth, Stephan] Univ Hosp Geneva, Geneva, Switzerland. [Gyssens, Inge C.] Hasselt Univ, Diepenbeek, Belgium.
Keywords: Immunology; Infectious Diseases; Microbiology
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ISSN: 1058-4838
e-ISSN: 1537-6591
DOI: 10.1093/cid/cir838
ISI #: 000298383700019
Category: A1
Type: Journal Contribution
Validations: ecoom 2013
Appears in Collections:Research publications

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