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http://hdl.handle.net/1942/13493
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DC Field | Value | Language |
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dc.contributor.author | BUNTINX, Mieke | - |
dc.contributor.author | AMELOOT, Marcel | - |
dc.contributor.author | STEELS, Paul | - |
dc.contributor.author | MEDAER, Rob | - |
dc.contributor.author | GEUSENS, Piet | - |
dc.contributor.author | RAUS, Jef | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.date.accessioned | 2012-03-29T13:20:41Z | - |
dc.date.available | 2012-03-29T13:20:41Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | JOURNAL OF NEUROIMMUNOLOGY, 118 (1), p. 94-94 | - |
dc.identifier.issn | 0165-5728 | - |
dc.identifier.uri | http://hdl.handle.net/1942/13493 | - |
dc.description.abstract | Autoreactive T-lymphocytes are considered to play a crucial role in orchestrating a chronic inflammation in the central nervous system CNS Ž . of multiple sclerosis MS patients and in the joints of rheumatoid Ž . arthritis RA patients. However, it has been suggested that the majority Ž . of T-cells in the immune infiltrate are nonspecifically recruited into the CNS and into the inflamed joint, respectively. Furthermore, several lines of evidence suggest an important role for interferon-g Ž . IFN-g in the pathogenesis of MS and RA. Here, we have studied whether peripheral blood T-cells from patients with autoimmune diseases are more susceptible to activation in the presence of IFN-g. The results indicate that IFN-g w mediates a sustained elevated Ca in T-cells of active MS and RA 2q x Ž . i patients as compared to healthy controls and patients with common viral w 2q x 2q infections. No Ca increase was observed in Ca -free medium, i excluding an effect of IFN-g on Ca 2q -release from intracellular stores. Although the IFN-g-activated Ca 2q influx is insufficient to induce T-cell proliferation in vitro, our data indicate a significantly augmented proliferation in response to suboptimal doses of PHA in the presence of IFN-g. This study suggests that the IFN-g-induced Ca 2q influx can act as a complementary mechanism in the activation of blood T-lymphocytes from MS and RA patients. | - |
dc.language.iso | en | - |
dc.title | Interferon-gamma-induced Ca2+-influx in T lymphocytes of Multiple Sclerosis and Rheumatoid Arthritis patients: A complementary mechanism for T cell activation? | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 94 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 94 | - |
dc.identifier.volume | 118 | - |
local.bibliographicCitation.jcat | M | - |
local.type.refereed | Refereed | - |
local.type.specified | Meeting Abstract | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1016/S0165-5728(01)00353-8 | - |
item.fulltext | No Fulltext | - |
item.accessRights | Closed Access | - |
item.fullcitation | BUNTINX, Mieke; AMELOOT, Marcel; STEELS, Paul; MEDAER, Rob; GEUSENS, Piet; RAUS, Jef & STINISSEN, Piet (2001) Interferon-gamma-induced Ca2+-influx in T lymphocytes of Multiple Sclerosis and Rheumatoid Arthritis patients: A complementary mechanism for T cell activation?. In: JOURNAL OF NEUROIMMUNOLOGY, 118 (1), p. 94-94. | - |
item.contributor | BUNTINX, Mieke | - |
item.contributor | AMELOOT, Marcel | - |
item.contributor | STEELS, Paul | - |
item.contributor | MEDAER, Rob | - |
item.contributor | GEUSENS, Piet | - |
item.contributor | RAUS, Jef | - |
item.contributor | STINISSEN, Piet | - |
crisitem.journal.issn | 0165-5728 | - |
crisitem.journal.eissn | 1872-8421 | - |
Appears in Collections: | Research publications |
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