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Title: | Interferon-gamma-induced Ca2+-influx in T lymphocytes of Multiple Sclerosis and Rheumatoid Arthritis patients: A complementary mechanism for T cell activation? | Authors: | BUNTINX, Mieke AMELOOT, Marcel STEELS, Paul MEDAER, Rob GEUSENS, Piet RAUS, Jef STINISSEN, Piet |
Issue Date: | 2001 | Source: | JOURNAL OF NEUROIMMUNOLOGY, 118 (1), p. 94-94 | Abstract: | Autoreactive T-lymphocytes are considered to play a crucial role in orchestrating a chronic inflammation in the central nervous system CNS Ž . of multiple sclerosis MS patients and in the joints of rheumatoid Ž . arthritis RA patients. However, it has been suggested that the majority Ž . of T-cells in the immune infiltrate are nonspecifically recruited into the CNS and into the inflamed joint, respectively. Furthermore, several lines of evidence suggest an important role for interferon-g Ž . IFN-g in the pathogenesis of MS and RA. Here, we have studied whether peripheral blood T-cells from patients with autoimmune diseases are more susceptible to activation in the presence of IFN-g. The results indicate that IFN-g w mediates a sustained elevated Ca in T-cells of active MS and RA 2q x Ž . i patients as compared to healthy controls and patients with common viral w 2q x 2q infections. No Ca increase was observed in Ca -free medium, i excluding an effect of IFN-g on Ca 2q -release from intracellular stores. Although the IFN-g-activated Ca 2q influx is insufficient to induce T-cell proliferation in vitro, our data indicate a significantly augmented proliferation in response to suboptimal doses of PHA in the presence of IFN-g. This study suggests that the IFN-g-induced Ca 2q influx can act as a complementary mechanism in the activation of blood T-lymphocytes from MS and RA patients. | Document URI: | http://hdl.handle.net/1942/13493 | ISSN: | 0165-5728 | e-ISSN: | 1872-8421 | DOI: | 10.1016/S0165-5728(01)00353-8 | Category: | M | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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