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Title: | Glutathione Is a Key Player in Metal-Induced Oxidative Stress Defenses | Authors: | JOZEFCZAK, Marijke REMANS, Tony VANGRONSVELD, Jaco CUYPERS, Ann |
Issue Date: | 2012 | Publisher: | MDPI AG | Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 132 (3), p. 3145-3175 | Abstract: | Since the industrial revolution, the production, and consequently the emission of metals, has increased exponentially, overwhelming the natural cycles of metals in many ecosystems. Metals display a diverse array of physico-chemical properties such as essential versus non-essential and redox-active versus non-redox-active. In general, all metals can lead to toxicity and oxidative stress when taken up in excessive amounts, imposing a serious threat to the environment and human health. In order to cope with different kinds of metals, plants possess defense strategies in which glutathione (GSH; gamma-glu-cys-gly) plays a central role as chelating agent, antioxidant and signaling component. Therefore, this review highlights the role of GSH in: (1) metal homeostasis; (2) antioxidative defense; and (3) signal transduction under metal stress. The diverse functions of GSH originate from the sulfhydryl group in cysteine, enabling GSH to chelate metals and participate in redox cycling. | Notes: | Cuypers, A (reprint author),Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Jozefczak, Marijke; Remans, Tony; Vangronsveld, Jaco; Cuypers, Ann] marijke.jozefczak@uhasselt.be; tony.remans@uhasselt.be; jaco.vangronsveld@uhasselt.be; ann.cuypers@uhasselt.be | Keywords: | Multidisciplinary Chemistry; metals; cellular redox state; glutathione; chelation;metals; cellular redox state; glutathione; chelation | Document URI: | http://hdl.handle.net/1942/13615 | ISSN: | 1661-6596 | e-ISSN: | 1422-0067 | DOI: | 10.3390/ijms13033145 | ISI #: | 000302174500038 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2013 |
Appears in Collections: | Research publications |
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