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Title: HTLV-1 infection is associated with a history of active tuberculosis among family members of HTLV-1-infected patients in Peru
Authors: Verdonck, K.
González, E.
Schrooten, W. 
Vanham, G.
Gotuzzo, E.
Issue Date: 2007
Source: EPIDEMIOLOGY AND INFECTION, 136 (8), p. 1076-1083
Abstract: SUMMARY:The purpose of this study was to assess the association between human T-lymphotropic virus 1 (HTLV-1) and a lifetime history of active tuberculosis (TB) among relatives of HTLV-1-infected patients. We reviewed clinical charts of all relatives of HTLV-1-infected index cases who attended our institute in Lima from 1990-2004. The data of 1233 relatives was analysed; 394 (32.0%) were HTLV-1 positive. Eighty-one subjects (6.6%) had a history of active TB, including 45/394 (11.4%) HTLV-1-positive and 36/839 (4.3%) HTLV-1-negative relatives (P<0.001). On multivariate analysis, three factors were associated with TB history: HTLV-1 infection (adjusted OR 2.5, 95% CI 1.6-3.9), age (adjusted OR 1.3, 95% CI 1.1-1.5 per 10-year age increase) and relation to the index case (adjusted OR 2.6, 95% CI 1.3-5.1, for siblings vs. spouses of index cases). In conclusion, HTLV-1 infection may increase the susceptibility to active TB. In populations where both infections are frequent, such an association could affect the dynamics of TB.
Document URI:
DOI: 10.1017/S0950268807009521
ISI #: 000259748200008
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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