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Title: | Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents | Authors: | van Puyenbroeck, Karolien HENS, Niel Coenen, Samuel Michiels, Barbara BEUNCKENS, Caroline MOLENBERGHS, Geert Van Royen, Paul Verhoeven, Veronique |
Issue Date: | 2012 | Publisher: | AMER SOC NUTRITION-ASN | Source: | AMERICAN JOURNAL OF CLINICAL NUTRITION, 95 (5), p. 1165-1171 | Abstract: | Background: Age is associated with immune dysregulation, which results in an increased infection rate and reduced effectiveness of vaccination. Objective: We assessed whether an intervention with Lactobacillus easel Shirota (LcS) in elderly nursing home residents reduced their susceptibility to respiratory symptoms and improved their immune response to influenza vaccination. Design: Between October 2007 and April 2008, a randomized, double-blind, placebo-controlled trial was conducted in 737 healthy people aged >= 65 y in 53 nursing homes in Antwerp, Belgium. Volunteers were randomly assigned to receive a probiotic (n = 375; 2 bottles of fermented milk that contained >= 6.5 x 10(9) live LcS/bottle) or a placebo (n = 362; similar drink with no bacteria) for 176 d. After 21 d, all subjects received an influenza vaccination. Primary outcome parameters were the number of days with respiratory symptoms, the probability of respiratory symptoms, and antiinfluenza antibody titer by hemagglutination inhibition after vaccination. Results: Univariate and multivariate modeling showed no effect of the probiotic on clinical outcome parameters. Generalized linear mixed modeling showed no effect of the probiotic itself on the probability of respiratory symptoms [OR of probiotic: 0.8715; 95% CI: 0.6168. 1.2887). No significant difference regarding the influenza-vaccination immune response was shown. Conclusion: The results of this study show that daily consumption of a fermented milk drink that contains LcS has no statistically or clinically significant effect on the protection against respiratory symptoms. This trial was registered at clinicaltrials.gov as NCT00849277. Am J Clin Nutr 2012;95:1165-71. | Notes: | [van Puyenbroeck, Karolien; Coenen, Samuel; Michiels, Barbara; Van Royen, Paul; Verhoeven, Veronique] Univ Antwerp, Dept Primary & Interdisciplinary Care, B-2610 Antwerp, Belgium. [Hens, Niel; Coenen, Samuel] Univ Antwerp, Vaccine & Infect Dis Inst, WHO Collaborating Ctr, B-2610 Antwerp, Belgium. [Hens, Niel] Univ Antwerp, Ctr Hlth Econ Res & Modeling Infect Dis, B-2610 Antwerp, Belgium. [Hens, Niel; Beunckens, Caroline; Molenberghs, Geert] Hasselt Univ, I BioStat, Diepenbeek, Belgium. [Hens, Niel; Beunckens, Caroline; Molenberghs, Geert] Katholieke Univ Leuven, Diepenbeek, Belgium. arolien.vanpuyenbroeck@ua.ac.be | Keywords: | Nutrition & Dietetics | Document URI: | http://hdl.handle.net/1942/13714 | ISSN: | 0002-9165 | e-ISSN: | 1938-3207 | DOI: | 10.3945/ajcn.111.026831 | ISI #: | 000303140700022 | Rights: | (C) 2012 American Society for Nutrition | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2013 |
Appears in Collections: | Research publications |
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Van Puyenbroeck et al. Am J Clin Nutr 2012.pdf | Published version | 209.98 kB | Adobe PDF | View/Open |
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