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Title: | Development of multichannel quartz crystal microbalances for MIP-based biosensing | Authors: | CROUX, Dieter WEUSTENRAED, Ans POBEDINSKAS, Paulius HOREMANS, Frederik DILIEN, Hanne HAENEN, Ken CLEIJ, Thomas WAGNER, Patrick THOELEN, Ronald DE CEUNINCK, Ward |
Issue Date: | 2012 | Publisher: | WILEY-V C H VERLAG GMBH | Source: | PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 209 (5), p. 892-899 | Abstract: | Molecularly imprinted polymers (MIPs) offer a huge potential in the development of cheap small-scale disposable biomimetic sensors. They are suited for a wide variety of biological targets and are compatible with many different measurement techniques such as gravimetric sensing and impedance spectroscopy. One potential sensor platform for MIP-based biosensors is the quartz crystal microbalance (QCM). A 4-channel MIP/non-imprinted polymer (NIP) coated QCM biosensor array was developed on a single piece of quartz crystal. To study cross-channel frequency coupling of the resonance modes, a simulation of crystal designs using finite element analysis (FEA) modeling was created. Based on these simulations and using reactive ion etching (RIE) to create mesa-like structures on the crystal surface, crosstalk can be severely reduced. The improved functionality compared to the traditional QCMs was demonstrated by employing these mesa-type multichannel QCM (MQCM) crystals as an L-nicotine biosensor platform. (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | Notes: | [Croux, Dieter; Weustenraed, Ans; Pobedinskas, Paulius; Horemans, Frederik; Dilien, Hanne; Haenen, Ken; Cleij, Thomas; Wagner, Patrick; De Ceuninck, Ward] Hasselt Univ, IMO, B-3590 Diepenbeek, Belgium. [Haenen, Ken; Wagner, Patrick; De Ceuninck, Ward] IMOMEC, IMEC VZW, B-3590 Diepenbeek, Belgium. [Thoelen, Ronald] XIOS Univ Coll, B-3590 Diepenbeek, Belgium. | Keywords: | biosensor; finite element analysis; molecular imprinting; quartz crystal microbalance;Multidisciplirary Materials Science; Applied Physics; Condensed Matter Physics; biosensor; finite element analysis; molecular imprinting; quartz crystal microbalance | Document URI: | http://hdl.handle.net/1942/13722 | ISSN: | 1862-6300 | e-ISSN: | 1862-6319 | DOI: | 10.1002/pssa.201100715 | ISI #: | 000303386900016 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2013 |
Appears in Collections: | Research publications |
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