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http://hdl.handle.net/1942/14192
Title: | Cell therapy in neonatal hypoxic ischemic encephalopathy | Authors: | De Munter, Stephanie | Advisors: | KRAMER, Boris W. | Issue Date: | 2012 | Publisher: | tUL Diepenbeek | Abstract: | Perinatal hypoxic-ischemic encephalopathy (HIE) is a major cause of preterm brain injury. In the Western world, there has been a tremendous increase in preterm birth rates over the past 20 years and the incidence of perinatal HIE is estimated at two to six per 1000 live-born infants. Currently, few treatment options are available for preterms suffering from HIE. In this translational research project, we hypothesize that Mesenchymal Stem Cells (MSC) and Granulocyte-Colony Stimulating Factor (G-CSF) therapies can reduce hypoxic-ischemic related synapse loss, neurodegeneration, microglial proliferation and damage to pre-oligodendrocytes in a fetal sheep model, thereby limiting preterm HIE. | Notes: | master in de biomedische wetenschappen-klinische moleculaire wetenschappen | Document URI: | http://hdl.handle.net/1942/14192 | Category: | T2 | Type: | Theses and Dissertations |
Appears in Collections: | Master theses |
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08265992011249.pdf | 4.14 MB | Adobe PDF | View/Open |
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