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Title: Active H(1)-receptors protect against the harmful effects of H(2)-receptors in a histamine induced brain edema model
Authors: DE JONGH, Rafael 
SMETS, Anke 
Nuydens, R.
RIGO, Jean-Michel 
MEERT, Theo 
Issue Date: 2009
Publisher: MEDIMOND S R L
Source: Baron, A Chneiweiss, H (Ed.). 9TH EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, p. 157-160
Abstract: Inspired by the high histamine levels in the brains of traumatic brain injury (TBI) patients and earlier in vitro results with histamine in a cell swelling model, a histamine induced brain ederna model was developed in rats. In this new experimental model, selective histamine agonists and antagonists were tested. An acute lethal effect is caused by H(1)-antagunism after intracerebroventricular (ICV) histamine infusion. Moreover H(2)-receptor activation results in toxic effects, which are reduced with H1-receptor stimulation. These data indicate that active H(1)-receptors protect against the toxic II,-effect. This shielding effect of H(1)-receptor activity is confirmed in several experiments. Therefore central penetrating H(1)-antagonists must be used with care in patients with a suspected elevated histamine concentration in the brain, for example TBI-patients.
Notes: [De Jongh, R.; Smets, A.; Rigo, J. M.; Meert, T.] Univ Hasselt, Biomed Res Unit BIOMED, Diepenbeek, Belgium.
Keywords: Clinical Neurology; Neurosciences
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ISBN: 978-88-7587-521-3
ISI #: 000292191900031
Category: C1
Type: Proceedings Paper
Validations: ecoom 2012
Appears in Collections:Research publications

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