Please use this identifier to cite or link to this item:
|Title:||Slowed Exercise-Onset Vo(2) Kinetics During Submaximal Endurance Exercise in Subjects With Multiple Sclerosis||Authors:||HANSEN, Dominique
EIJNDE, Bert O.
|Issue Date:||2013||Publisher:||SAGE PUBLICATIONS INC||Source:||NEUROREHABILITATION AND NEURAL REPAIR, 27 (1), p. 87-95||Abstract:||Background. Low physical activity levels in persons with multiple sclerosis (MS) may reduce skeletal muscle oxidative capacity. Rehabilitation strategies might be altered by a measure of capacity that did not require invasive techniques or maximal exercise testing. For this purpose, we measured exercise onset and offset oxygen uptake (Vo(2)) kinetics during endurance exercise. Objective. This study compared exercise-onset and -offset Vo(2) kinetics in mildly affected persons with MS with healthy matched participants. Methods. From 38 MS patients who had a mean Expanded Disability Status Scale of 3.1 and 16 healthy participants, exercise-onset and -offset Vo(2) kinetics (mean response time [MRT]) were determined during two 6-minute submaximal bouts of exercise separated by a 6-minute recovery interval. Blood lactate, heart rate, expiratory volume, and Borg ratings of perceived exertion were assessed during exercise and compared between groups. Relationships between clinical characteristics and MRT were assessed. Results. During exercise, blood lactate, heart rate, and expiratory volume did not differ between groups (P > .05), but exercise-onset MRT was significantly slower in MS versus healthy participants (P = .007). Exercise-onset MRT was independently related to having MS (P = .02). Exercise-offset MRT was not different between groups or was independently related to having MS (P > .05). No independent relationships between clinical characteristics of MS and exercise-onset or -offset MRT were found. Conclusions. Exercise-onset Vo(2) kinetics during submaximal endurance exercise are significantly slowed in mildly disabled persons with MS, suggesting low skeletal muscle oxidative capacity. Using mean response time testing, rehabilitation interventions for this reduction in exercise capacity can be assessed and targeted.||Notes:||[Hansen, Dominique] Hasselt Univ, Rehabil Res Ctr, Biomed Res Inst, Fac Med & Life Sci, B-3590 Diepenbeek, Belgium. firstname.lastname@example.org||Keywords:||multiple sclerosis rehabilitation; endurance exercise; exercise testing; oxygen uptake kinetics; mean response time; oxidative capacity;Clinical Neurology; Rehabilitation; multiple sclerosis rehabilitation; endurance exercise; oxygen uptake kinetics; mean response time; oxidative capacity||Document URI:||http://hdl.handle.net/1942/14603||ISSN:||1545-9683||e-ISSN:||1552-6844||DOI:||10.1177/1545968312451916||ISI #:||000311853400010||Category:||A1||Type:||Journal Contribution||Validations:||ecoom 2013|
|Appears in Collections:||Research publications|
Show full item record
Files in This Item:
|slowed exercise onset VO2.pdf|
|published version||689.55 kB||Adobe PDF||View/Open Request a copy|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.