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http://hdl.handle.net/1942/1468
Title: | Surrogate Marker Evaluation from an Information Theory Perspective | Authors: | ALONSO ABAD, Ariel MOLENBERGHS, Geert |
Issue Date: | 2006 | Publisher: | Blackwell | Source: | BIOMETRICS, 63(1). p. 180-186 | Abstract: | The last 20 years have seen lots of work in the area of surrogate marker validation, partly devoted to frame the evaluation in a multitrial framework, leading to definitions in terms of the quality of trial- and individual-level association between a potential surrogate and a true endpoint (Buyse et al., 2000, Biostatistics 1, 49–67). A drawback is that different settings have led to different measures at the individual level. Here, we use information theory to create a unified framework, leading to a definition of surrogacy with an intuitive interpretation, offering interpretational advantages, and applicable in a wide range of situations. Our method provides a better insight into the chances of finding a good surrogate endpoint in a given situation. We further show that some of the previous proposals follow as special cases of our method. We illustrate our methodology using data from a clinical study in psychiatry. | Keywords: | hierarchical model; information theory; surrogate endpoints | Document URI: | http://hdl.handle.net/1942/1468 | ISSN: | 0006-341X | e-ISSN: | 1541-0420 | DOI: | 10.1111/j.1541-0420.2006.00634.x | ISI #: | 000244647100020 | Rights: | (C) 2006, The International Biometric Society | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2008 |
Appears in Collections: | Research publications |
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Alonso_et_al-2007-Biometrics.pdf Restricted Access | Published version | 117.22 kB | Adobe PDF | View/Open Request a copy |
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