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http://hdl.handle.net/1942/14729
Title: | Simultaneous Inferences for Ratio Parameters Using Multiple Contrasts Test | Authors: | LIN, Dan Djira, Gemechis D. SHKEDY, Ziv BURZYKOWSKI, Tomasz Hothorn, Ludwig A. |
Issue Date: | 2012 | Publisher: | Springer | Source: | Lin, D.; Shkedy, Z.; Yekutieli, D.; Amaratunga, D.; Bijnens, L. (Ed.). Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R: Order-Restricted Analysis of Microarray Data, p. 249-258 | Series/Report: | Use R! | Abstract: | In chap.16, we wish to search for genes for which the mean gene-expression increases by 100 ×δ% from the control for at least one (perhaps the highest) dose, where δ is a relative biological ratio of interest. Genes can be tested for a pre-specified δ and can be ranked based on the significance of the ratio test. Genes found significant with a large δ are of higher interest to the biologists. We discuss the ratio test statistic and the link between Williams- and Marcus-type multiple contrasts tests (MCTs) and the corresponding ratio testing procedures. | Document URI: | http://hdl.handle.net/1942/14729 | Link to publication/dataset: | http://www.ibiostat.be/software/IsoGeneGUI/Book.html | ISBN: | 9783642240065 | DOI: | 10.1007/978-3-642-24007-2_16 | Category: | B2 | Type: | Book Section |
Appears in Collections: | Research publications |
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Simultaneous.pdf Restricted Access | Peer-reviewed author version | 292.74 kB | Adobe PDF | View/Open Request a copy |
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