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http://hdl.handle.net/1942/15423
Title: | Reduced graphene oxide micropatterns as an interface for adherent cells | Authors: | DELLE, Lotta Lanche, Ruben Law, Jessica Ka-Yan Weil, Maryam Xuan Thang, Vu WAGNER, Patrick Ingebrandt, Sven |
Issue Date: | 2013 | Publisher: | WILEY-V C H VERLAG GMBH | Source: | PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 210 (5), p. 975-982 | Abstract: | In the present study, reduced graphene oxide (rGO) is used as a biointerface for the investigation of cell adhesion of human embryonic kidney (HEK 293) cells. A fast, straightforward, and substrate-independent soft lithography approach known as Micromolding In Capillaries (MIMIC) was utilized to pattern graphene oxide (GO) arrays. Large-scale GO patterns with widths and distances in the micrometer range were obtained and were subsequently reduced to rGO via an environmentally-friendly procedure using L-ascorbic acid. Physical characterization of rGO patterns and cells was performed by optical microscopy, atomic force microscopy, and scanning electron microscopy. Impedance spectroscopy was used for the electrochemical characterization of GO before and after reduction. Cell adhesion and alignment was strong on the rGO micropatterns. In future assays, the rGO could combine two functions: cellular patterning and electrical interfacing of cells. HEK 293 cells aligning on rGO micro patterns (SEM image) | Notes: | Univ Appl Sci Kaiserslautern, Dept Informat & Microsyst Technol, D-66482 Zweibrucken, Germany. Hasselt Univ, Inst Mat Res, B-3590 Diepenbeek, Belgium. | Keywords: | cell adhesion; impedance spectroscopy; reduced graphene oxide; scanning electron microscopy;Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter | Document URI: | http://hdl.handle.net/1942/15423 | ISSN: | 1862-6300 | e-ISSN: | 1862-6319 | DOI: | 10.1002/pssa.201200864 | ISI #: | 000319151900024 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2014 |
Appears in Collections: | Research publications |
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