Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/15487
Title: Anodal tDCS increases corticospinal output and projection strength in multiple sclerosis
Authors: CUYPERS, Koen 
LEENUS, Daphnie 
VAN WIJMEERSCH, Bart 
THIJS, Herbert 
Levin, Oron
Swinnen, Stephan
MEESEN, Raf 
Issue Date: 2013
Source: NEUROSCIENCE LETTERS, 554, p.151–155
Abstract: The application of anodal transcranial direct current stimulation (atDCS) to the human brain has been shown to elicit corticospinal (CS) excitability changes. This study evaluated the effect of a single session of atDCS on CS excitability in patients with multiple sclerosis (MS). atDCS and sham tDCS (stDCS) were applied to the primary motor cortex (M1) contralateral to the more severely impaired hand for 20 minutes in a double-blinded crossover design. Changes in CS excitability were assessed using transcranial magnetic stimulation (TMS). The area under the recruitment curves increased significantly after application of atDCS (+ 56.58%, p = 0.023) but not after stDCS. A sigmoidal curve- analysis revealed a higher plateau of the curve after atDCS (+22.2%, p < 0.001). Our results showed that atDCS over M1 has the ability to increase CS output and projection strength in MS-patients, suggesting that atDCS can be considered during neural rehabilitation to facilitate motor recovery in MS.
Notes: Meesen, RLJ (reprint author), Hasselt Univ, REVAL Res Inst, Agoralaan,Bldg A, B-3590 Diepenbeek, Belgium. E-mail Addresses:koen.cuypers@uhasselt.be
Keywords: Multiple sclerosis; tDCS; TMS; Corticospinal excitability; Recruitment curve
Document URI: http://hdl.handle.net/1942/15487
ISSN: 0304-3940
e-ISSN: 1872-7972
DOI: 10.1016/j.neulet.2013.09.004
ISI #: 000327674600029
Category: A1
Type: Journal Contribution
Validations: ecoom 2014
Appears in Collections:Research publications

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