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Title: | Prevalence and spread of multidrug-resistant Escherichia coli including ST131 in different patient populations in the Euroregion Meuse-Rhine | Authors: | van der Donk, Christina van de Bovenkamp, Jeroen Bamelis, Hans Driessen, Christel Feldhoff, Karl-Heinz Kalka-Moll, Wiltrud MAGERMAN, Koen Stobberingh, Ellen |
Issue Date: | 2013 | Source: | FUTURE MICROBIOLOGY, 8 (8), p. 1027-1037 | Abstract: | Aim: To investigate the prevalence and genetic background of Escherichia coli collected from different patient populations in the Euroregion Meuse-Rhine. Materials & methods: Susceptibility testing was performed on 1651 E. coli isolates with broth microdilution. Their genetic background was determined using pulsed-field gel electrophoresis and multilocus sequence typing. Results: The prevalence of resistance varied significantly between the populations. Approximately 10% of the E. coli isolates were multidrug-resistant and/or a β-lactamase producer. The most prevalent extended-spectrum β-lactamase type was CTX-M-15 and ST131 was the most prevalent multilocus sequence typing type. Results from pulsed-field gel electrophoresis of the ST131 isolates indicate the spread of these isolates in the Euroregion. Conclusion: E. coli ST131 was the most prevalent sequence type in our Euroregional study. It is essential to control the spread of these resistant strains (e.g., with infection-control policies, antibiotic stewardship programs and antibiotic resistance surveillance). In this way we could observe shifts in the prevalence of resistance of the E. coli population and act accordingly. | Notes: | Stobberingh, E (reprint author), Maastricht Univ, Dept Med Microbiol, Med Ctr, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands. e.stobberingh@gmail.com | Keywords: | antibiotic resistance; cross-border; Escherichia coli; extended-spectrum beta-lactamases; multilocus sequence typing; ST131 | Document URI: | http://hdl.handle.net/1942/15502 | ISSN: | 1746-0913 | e-ISSN: | 1746-0921 | DOI: | 10.2217/FMB.13.61 | ISI #: | 000323229800014 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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