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Title: Prevalence and spread of multidrug-resistant Escherichia coli including ST131 in different patient populations in the Euroregion Meuse-Rhine
Authors: van der Donk, Christina
van de Bovenkamp, Jeroen
Bamelis, Hans
Driessen, Christel
Feldhoff, Karl-Heinz
Kalka-Moll, Wiltrud
Stobberingh, Ellen
Issue Date: 2013
Source: FUTURE MICROBIOLOGY, 8 (8), p. 1027-1037
Abstract: Aim: To investigate the prevalence and genetic background of Escherichia coli collected from different patient populations in the Euroregion Meuse-Rhine. Materials & methods: Susceptibility testing was performed on 1651 E. coli isolates with broth microdilution. Their genetic background was determined using pulsed-field gel electrophoresis and multilocus sequence typing. Results: The prevalence of resistance varied significantly between the populations. Approximately 10% of the E. coli isolates were multidrug-resistant and/or a β-lactamase producer. The most prevalent extended-spectrum β-lactamase type was CTX-M-15 and ST131 was the most prevalent multilocus sequence typing type. Results from pulsed-field gel electrophoresis of the ST131 isolates indicate the spread of these isolates in the Euroregion. Conclusion: E. coli ST131 was the most prevalent sequence type in our Euroregional study. It is essential to control the spread of these resistant strains (e.g., with infection-control policies, antibiotic stewardship programs and antibiotic resistance surveillance). In this way we could observe shifts in the prevalence of resistance of the E. coli population and act accordingly.
Notes: Stobberingh, E (reprint author), Maastricht Univ, Dept Med Microbiol, Med Ctr, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
Keywords: antibiotic resistance; cross-border; Escherichia coli; extended-spectrum beta-lactamases; multilocus sequence typing; ST131
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ISSN: 1746-0913
e-ISSN: 1746-0921
DOI: 10.2217/FMB.13.61
ISI #: 000323229800014
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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