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|Title:||Characterization of biodegradable polymers with capacitive field-effect sensors||Authors:||Schusser, S.
Schoening, M. J.
|Issue Date:||2013||Publisher:||ELSEVIER SCIENCE SA||Source:||SENSORS AND ACTUATORS B-CHEMICAL, 187, p. 2-7||Abstract:||In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta2O5-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance-voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor. (C) 2012 Elsevier B. V. All rights reserved.||Notes:||[Schusser, S.; Poghossian, A.; Baecker, M.; Leinhos, M.; Schoening, M. J.] Aachen Univ Appl Sci, Inst Nano & Biotechnol INB, D-52428 Julich, Germany. [Schusser, S.; Poghossian, A.; Baecker, M.; Leinhos, M.; Schoening, M. J.] Forschungszentrum Julich, Peter Grunberg Inst PGI 8, D-52525 Julich, Germany. [Wagner, P.] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. email@example.com||Keywords:||Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation;Field-effect sensor; (Bio)degradation; Poly(D,L-lacticacid); Real-time monitoring; C-V method; Impedance spectroscopy||Document URI:||http://hdl.handle.net/1942/15843||e-ISSN:||0925-4005||DOI:||10.1016/j.snb.2012.07.099||ISI #:||000324298300002||Category:||A1||Type:||Journal Contribution||Validations:||ecoom 2014|
|Appears in Collections:||Research publications|
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