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http://hdl.handle.net/1942/1633
Title: | T-cell-based immunotherapy in multiple sclerosis: induction of regulatory immune networks by T-cell vaccination | Authors: | HELLINGS, Niels RAUS, Jef STINISSEN, Piet |
Issue Date: | 2006 | Publisher: | Future drugs | Source: | Expert Review of Clinical Immunology, 2(5). p. 705-716 | Abstract: | Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS with presumed autoimmune origin. Pathogenic autoimmune responses in MS are thought to be the result of a breakdown of self tolerance. Several mechanisms account for the natural state of immunological tolerance to self antigens, including clonal deletion of self-reactive T cells in the thymus. However, autoimmune T cells are also part of the normal T-cell repertoire, supporting the existence of peripheral regulatory mechanisms that keep these potentially pathogenic T cells under control. One such mechanism involves active suppression by regulatory T cells. It has been indicated that regulatory T cells do not function properly in autoimmune disease. Immunization with attenuated autoreactive T cells, T-cell vaccination, may enhance or restore the regulatory immune networks to specifically suppress autoreactive T cells, as shown in experimental autoimmune encephalomyelitis, an animal model for MS. In the past decade, T-cell vaccination has been tested for MS in several clinical trials. This review summarizes these clinical trials and updates our current knowledge on the induction of regulatory immune networks by T cell vaccination. | Keywords: | anticlonotypic T cells; antiergotypic T cells; autoreactive T cells; Qa-1-dependent T cells; regulatory networks; T-cell vaccination | Document URI: | http://hdl.handle.net/1942/1633 | ISSN: | 1744-666X | e-ISSN: | 1744-8409 | DOI: | 10.1586/1744666X.2.5.705 | Rights: | 2006 Future Drugs Ltd | Category: | A2 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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