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Title: Morphological matching of proximal interphalangeal (PIP) joint arthritis-related entheses
Authors: VAN ZWIETEN, Koos Jaap 
KOSTEN, Lauren
DE MUNTER, Stephanie
Issue Date: 2014
Source: Knowledge for Growth, 10th (anniversary!) Edition of Flanders Bio Annual Life Sciences Convention, Ghent - Belgium, 08/05/2014
Abstract: The bony attachments of the PIP (proximal interphalangeal) joint's collateral ligaments of the finger, are known as the so-called entheses. Enthesitis as a key-mechanism in human arthritis was investigated by various authors (e.g., McGonagle et al., 2003). Therefore we carried out a meticulous morphological reappraisal, based on coronal HR-MRI slices of a normal anatomical specimen of an extended PIP joint (Lippens et al. , 1997). Additional coronal histological sections (Masson Trichrome & Weigert Orcein staining) of a PIP collateral ligament from a normal finger anatomical specimen, observed under low power magnification, reveal crisscrossing of collagen fiber bundles with virtually no elasticity. This contrasts with the simple parallelism of collagen fibers as sketched in the diagrams from literature.
Notes: Parts of the results were presented in two recent Biomedical Sciences Junior Master Theses (MSc Clinical Molecular Sciences), University of Hasselt, Belgium.
Keywords: rheumatoid arthritis; proximal interphalangeal (PIP) joint of the finger; entheses; HR-MRI; PIP joint collateral ligament; histology
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Rights: Knowledge for Growth, 10th Edition, Ghent, FlandersBio, Jonas De Backer, Communications Coordinator FlandersBio. More information on
Category: C2
Type: Conference Material
Appears in Collections:Research publications

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