Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16546
Title: Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets.
Authors: VANMIERLO, Tim 
Prickaerts, Jos
Gieling, Elise T.
Bruder, Ann K.
van der Staay, Franz J.
Issue Date: 2014
Source: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 33, p. 29-32
Abstract: In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expression of plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets. ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronal plasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic marker PSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to a similar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administered in the last trimester might be a promising treatment for LBW neonates.
Notes: Vanmierlo, T (reprint author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Biochem, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium, tim.vanmierlo@uhasselt.be
Keywords: allopurinol; low birth weight; BDNF; neuronal plasticity; pig
Document URI: http://hdl.handle.net/1942/16546
ISSN: 0736-5748
e-ISSN: 1873-474X
DOI: 10.1016/j.ijdevneu.2013.11.001
ISI #: 000333002800005
Rights: © 2013 ISDN. Published by Elsevier Ltd. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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