Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16699
Title: Prognostic value of circulating cytokines on overall survival and disease-free survival in cancer patients
Authors: VISCONTI, Laura 
NELISSEN, Katherine 
Deckx, Laura
van den Akker, Marjan
Adriaensen, Wim
Daniels, Liesbeth
Mathei, Cathy
LINSEN, Loes 
HELLINGS, Niels 
STINISSEN, Piet 
Buntinx, Frank
Issue Date: 2014
Source: BIOMARKERS IN MEDICINE, 8 (2), p. 297-306
Abstract: Through their tumor-promoting and/or tumor-suppressive properties, cytokines can influence progression of cancer. We systematically reviewed the current literature on the prognostic value of the circulating cytokines IL-1α/β, IL-6, IL-8, IL-10, IL-12, TNF-α, TGF-β and IFN-γ to predict overall and disease-free survival in any type of cancer patients. PubMed was systematically searched and based on eligibility assessment using our five criteria of the Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) checklist, six unique studies were reviewed. Elevated IL-6 and IL-10 levels seem independently associated with worse prognosis in terms of overall and disease-free survival. The prognostic value of IL-1α/β, IL-8, IL-12, TNF-α, TGF-β and IFN-γ could not be demonstrated. The small number of selected studies underlines the need for large well-designed prospective studies, using the REMARK checklist as a guideline, to determine which cytokines have prognostic value on survival in cancer patients.
Notes: Visconti, L (reprint author), Hasselt Univ, Fac Med & Life Sci, Campus Diepenbeek,Martelarenlaan 42, B-3500 Hasselt, Belgium laura.visconti@uhasselt.be
Keywords: cytokines; mortality; neoplasms; prognosis
Document URI: http://hdl.handle.net/1942/16699
ISSN: 1752-0363
e-ISSN: 1752-0371
DOI: 10.2217/bmm.13.122
ISI #: 000331212400025
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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