Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/16712
Title: | Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure | Authors: | Adamopoulos, Stamatis Schmid, Jean-Paul DENDALE, Paul Poerschke, Daniel HANSEN, Dominique Dritsas, Athanasios Kouloubinis, Alexandros Alders, Toon Gkouziouta, Aggeliki REYCKERS, Ilse Vartela, Vasiliki Plessas, Nikos Doulaptsis, Costas Saner, Hugo Laoutaris, Ioannis D. |
Issue Date: | 2014 | Source: | EUROPEAN JOURNAL OF HEART FAILURE, 16 (5), p. 574-582 | Abstract: | Aims Vent-HeFT is a multicentre randomized trial designed to investigate the potential additive benefits of inspiratory muscle training (IMT) on aerobic training (AT) in patients with chronic heart failure (CHF). Methods and results Forty-three CHF patients with a mean age of 58 ± 12 years, peak oxygen consumption (peak VO2) 17.9 ± 5 mL/kg/min, and LVEF 29.5 ± 5% were randomized to an AT/IMT group (n = 21) or to an AT/SHAM group (n = 22) in a 12-week exercise programme. AT involved 45 min of ergometer training at 70–80% of maximum heart rate, three times a week for both groups. In the AT/IMT group, IMT was performed at 60% of sustained maximal inspiratory pressure (SPImax) while in the AT/SHAM group it was performed at 10% of SPImax, using a computer biofeedback trainer for 30 min, three times a week. At baseline and at 3 months, patients were evaluated for exercise capacity, lung function, inspiratory muscle strength (PImax) and work capacity (SPImax), quality of life (QoL), LVEF and LV diameter, dyspnoea, C-reactive protein (CRP), and NT-proBNP. IMT resulted in a significantly higher benefit in SPImax (P = 0.02), QoL (P = 0.002), dyspnoea (P = 0.004), CRP (P = 0.03), and NT-proBNP (P = 0.004). In both AT/IMT and AT/SHAM groups PImax (P < 0.001, P = 0.02), peak VO2 (P = 0.008, P = 0.04), and LVEF (P = 0.005, P = 0.002) improved significantly; however, without an additional benefit for either of the groups. Conclusion This randomized multicentre study demonstrates that IMT combined with aerobic training provides additional benefits in functional and serum biomarkers in patients with moderate CHF. These findings advocate for application of IMT in cardiac rehabilitation programmes. | Notes: | Laoutaris, ID (reprint author),Onassis Cardiac Surg Ctr, Stress Testing & Rehabil Dept, 356 Sygrou Blv, Athens 17674, Greece, ylaoutaris@yahoo.gr | Keywords: | aerobic training; inspiratory muscle training; chronic heart failure; quality of life; exercise; rehabilitation; Vent-HeFT trial | Document URI: | http://hdl.handle.net/1942/16712 | ISSN: | 1388-9842 | e-ISSN: | 1879-0844 | DOI: | 10.1002/ejhf.70 | ISI #: | 000335444200012 | Rights: | © 2014 The Authors. European Journal of Heart Failure © 2014 European Society of Cardiology. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2015 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Vent-HeFT trial manuscript.10.1002-ejhf.70.pdf Restricted Access | Published version | 737.79 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
41
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
73
checked on Sep 28, 2024
Page view(s)
72
checked on Sep 7, 2022
Download(s)
106
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.