Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/16784
Title: Polymer End Group Modifications and Polymer Conjugations via " Click" Chemistry Employing Microreactor Technology
Authors: VANDENBERGH, Joke 
Tura, Tiago
BAETEN, Evelien 
JUNKERS, Tanja 
Issue Date: 2014
Source: JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 52 (9), p. 1263-1274
Abstract: This study presents the development of microreactor protocols for the successful continuous flow end group modification of atom transfer radical polymerization precursor polymers into azide end-capped materials and the subsequent copper-catalyzed azide alkyne click reactions with alkyne polymers, in flow. By using a microreactor, the reaction speed of the azidation of poly(butyl acrylate), poly(methyl acrylate), and polystyrene can be accelerated from hours to seconds and full end group conversion is obtained. Subsequently, coppercatalyzed click reactions are executed in a flow reactor at 80 C. Good coupling efficiencies are observed and various block copolymer combinations are prepared. Furthermore, the flow reaction can be carried out in only 40 min, while a batch procedure takes several hours to reach completion. The results indicate that the use of a continuous flow reactor for end group modifications as well as click reactions has clear benefits towards the development and improvement of well-defined polymer materials.
Notes: Junkers, T (reprint author), Univ Hasselt, Inst Mat Res IMO Imomec, Polymer React Design Grp, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. thomas.junkers@uhasselt.be
Keywords: atom transfer radical polymerization (ATRP); azidation; click chemistry; click reactions; diblock copolymers; microflow chemistry; microreactor technology; radical polymerization; reversible addition fragmentation chain transfer (RAFT)
Document URI: http://hdl.handle.net/1942/16784
ISSN: 0887-624X
e-ISSN: 1099-0518
DOI: 10.1002/pola.27112
ISI #: 000333310800005
Rights: © 2014 Wiley Periodicals, Inc.
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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