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Title: | Within-day variability on short and long walking tests in persons with multiple sclerosis | Authors: | FEYS, Peter Bibby, Bo Romberg, Anders Santoyo, Carme GEBARA, Benoit de Noordhout, Benoit Maertens Knuts, Kathy Bethoux, Francois Skjerbaek, Anders Jensen, Ellen BAERT, Ilse Vaney, Claude de Groot, Vincent Dalgas, Ulrik |
Issue Date: | 2014 | Source: | JOURNAL OF THE NEUROLOGICAL SCIENCES, 338 (1-2), p. 183-187 | Abstract: | Objective: To compare within-day variability of short (10 mwalking test at usual and fastest speed; 10MWT) and long (2 and 6-minute walking test; 2MWT/6MWT) tests in persons with multiple sclerosis. Design: Observational study. Setting: MS rehabilitation and research centers in Europe and US within RIMS (European network for best practice and research in MS rehabilitation). Subjects: Ambulatory persons with MS (Expanded Disability Status Scale 0–6.5). Intervention: Subjects of different centers performed walking tests at 3 time points during a single day. Main measures: 10MWT, 2MWT and 6MWT at fastest speed and 10MWT at usual speed. Ninety-five percent limits of agreement were computed using a random effects model with individual pwMS as random effect. Following this model, retest scores are with 95% certainty within these limits of baseline scores. Results: In 102 subjects,within-day variability was constant in absolute units for the 10MWT, 2MWT and 6MWT at fastest speed (+/−0.26, 0.16 and 0.15 m/s respectively, corresponding to +/−19.2 m and +/−54 mfor the 2MWT and 6MWT) independent on the severity of ambulatory dysfunction. This implies a greater relative variability with increasing disability level, often above 20% depending on the applied test. The relative within-day variability of the 10MWT at usual speed was +/−31% independent of ambulatory function. Conclusions: Absolute values of within-day variability on walking tests at fastest speed were independent of disability level and greater with short compared to long walking tests. Relative within-day variability remained overall constant when measured at usual speed. | Notes: | Feys, P (reprint author),Univ Hasselt, REVAL BIOMED Res Inst, Martelarenlaan 42, B-3500 Hasselt, Belgium. Peter.Feys@uhasselt.be | Keywords: | multiple sclerosis; walking; outcome measures; variability; 10 meter walk test; 6 minute walking test | Document URI: | http://hdl.handle.net/1942/16799 | ISSN: | 0022-510X | e-ISSN: | 1878-5883 | DOI: | 10.1016/j.jns.2014.01.001 | ISI #: | 000333883400032 | Rights: | Crown Copyright © 2014 Published by Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2015 |
Appears in Collections: | Research publications |
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