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http://hdl.handle.net/1942/17126
Title: | Changes in Corticomotor Excitability and Intracortical Inhibition of the Primary Motor Cortex Forearm Area Induced by Anodal tDCS | Authors: | Zhang, Xue Woolley, Daniel G. Swinnen, Stephan P. Feys, Hilde MEESEN, Raf Wenderoth, Nicole |
Issue Date: | 2014 | Source: | PLOS ONE, 9 (7) | Abstract: | Objective: Previous studies have investigated how tDCS over the primary motor cortex modulates excitability in the intrinsic hand muscles. Here, we tested if tDCS changes corticomotor excitability and/or cortical inhibition when measured in the extensor carpi radialis (ECR) and if these aftereffects can be successfully assessed during controlled muscle contraction. Methods: We implemented a double blind cross-over design in which participants (n = 16) completed two sessions where the aftereffects of 20 min of 1 mA (0.04 mA/cm(2)) anodal vs sham tDCS were tested in a resting muscle, and two more sessions where the aftereffects of anodal vs sham tDCS were tested in an active muscle. Results: Anodal tDCS increased corticomotor excitability in ECR when aftereffects were measured with a low-level controlled muscle contraction. Furthermore, anodal tDCS decreased short interval intracortical inhibition but only when measured at rest and after non-responders (n = 2) were removed. We found no changes in the cortical silent period. Conclusion: These findings suggest that targeting more proximal muscles in the upper limb with anodal tDCS is achievable and corticomotor excitability can be assessed in the presence of a low-level controlled contraction of the target muscle. | Notes: | Wenderoth, N (reprint author), Katholieke Univ Leuven, Dept Kinesiol, Motor Control Lab, Movement Control & Neuroplast Res Grp, Leuven, Belgium.nicole.wenderoth@hest.ethz.ch | Document URI: | http://hdl.handle.net/1942/17126 | ISSN: | 1932-6203 | e-ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0101496 | ISI #: | 000338637300050 | Rights: | © 2014 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2015 |
Appears in Collections: | Research publications |
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