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Title: Whole-body cooling does not compromise muscle oxidative capacity in subjects with multiple sclerosis.
Authors: OP 'T EIJNDE, Bert 
WENS, Inez 
HANSEN, Dominique 
Issue Date: 2014
Source: NEUROREHABILITATION, 35 (4), p. 805-811
Abstract: BACKGROUND: Whole-body cooling improves exercise tolerance in patients with multiple sclerosis (pwMS). To be able to exercise at greater intensities and/or for longer durations with whole-body cooling, it should be examined whether this compromises skeletal muscle oxidative capacity (assessed by exercise-onset VO2 kinetics). OBJECTIVE: To study the impact of whole-body cooling on exercise-onset VO2 kinetics in pwMS. METHODS: From 12 pwMS (EDSS 3.5 ± 1.5) and 12 healthy age, BMI, and gender-matched subjects exercise-onset VO2 kinetics (mean response time [MRT]) and body temperature were determined under normothermic and hypothermic (pre-exercise 60-min whole-body cooling) conditions during submaximal exercise testing (two 6-min constant-load exercise bouts). Moreover, heart rate, blood lactate content, expiratory volume and ratings of perceived exertion (RPE) were assessed during exercise. RESULTS: Exercise heart rate (−7 ± 6 beats/min) and end-exercise body temperature (−0.9 ± 0.5◦C) was significantly lower in hypothermic vs. normothermic conditions in both populations (p < 0.05). In pwMS exercise RPE was lower in hypothermic vs. normothermic condition (p = 0.056). No significantly different MRT was found between normothermic vs. hypothermic conditions in both populations. CONCLUSIONS: Lowering body temperature prior to endurance exercise does not affect muscle oxidative capacity in pwMS, but lowers RPE, thus making it possible to prescribe exercises of greater intensity and/or longer duration.
Notes: 't Eijnde, BO (reprint author), Hasselt Univ, REVAL Rehabil Res Ctr, Biomed Res Inst BIOMED, Agoralaan Bldg A, B-3590 Diepenbeek, Belgium.
Keywords: multiple sclerosis; endurance exercise; oxygen uptake kinetics; oxidative capacity; whole-body cooling
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ISSN: 1053-8135
e-ISSN: 1878-6448
DOI: 10.3233/NRE-141159
ISI #: 000346241600019
Rights: © 2014 – IOS Press and the authors. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2016
Appears in Collections:Research publications

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