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Title: Asymptomatic episodes of device-registered atrial tachyarrhythmia are not associated with worse cardiac resynchronization therapy response
Authors: VERBRUGGE, Frederik 
NIJST, Petra 
Van Herendael, Hugo
DE VUSSER, Philip 
Jacobs, Linda
Vercammen, Jan
Verhaert, David
DUPONT, Matthias 
MULLENS, Wilfried 
Rivero-Ayerza, Maximo
Issue Date: 2014
Source: EUROPACE, 16 (8), p. 1197-1204
Abstract: To assess the influence of device-registered episodes of atrial tachyarrhythmia (AT) on the response to cardiac resynchronization therapy (CRT). Consecutive CRT patients without history of atrial fibrillation (AF; n = 118) were followed prospectively. AT was defined as a device-registered episode of atrial rate > 190 b.p.m. for a parts per thousand yen30 s. Episodes of electrocardiographically documented AF, accompanied by symptoms, or need for cardioversion, were classified as clinical AF. During mean follow-up of 26 +/- 9 months, 39 patients (33%) had a parts per thousand yen1 episode of asymptomatic device-registered AT. Twenty-one patients (18%) developed clinical AF of whom seven had previously experienced episodes of asymptomatic device-registered AT. Patients with asymptomatic AT or AF had a higher body mass index, but otherwise similar baseline characteristics, compared with the subjects without AT. Reverse remodelling after CRT was similar among the groups. While clinical AF was significantly associated with the composite endpoint of all-cause mortality or unplanned hospital admission (hazard ratio = 2.43, 95% confidence interval: 1.40-4.24), this correlation was not observed in patients with asymptomatic device-registered AT (P value = 0.540). Episodes of asymptomatic device-registered AT are frequent in CRT patients, but are not associated with impaired reverse remodelling. In contrast to clinical AF, such episodes are not associated with worse clinical outcome.
Notes: [Verbrugge, Frederik Hendrik; Nijst, Petra; Van Herendael, Hugo; De Vusser, Philip; Jacobs, Linda; Vercammen, Jan; Verhaert, David; Vandervoort, Pieter; Dupont, Matthias; Mullens, Wilfried; Rivero-Ayerza, Maximo] Ziekenhuis Oost Limburg, Dept Cardiol, B-3600 Genk, Belgium. [Verbrugge, Frederik Hendrik; Nijst, Petra] Hasselt Univ, Sch Med & Life Sci, B-3590 Diepenbeek, Belgium. [Vandervoort, Pieter; Mullens, Wilfried] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, B-3590 Diepenbeek, Belgium.
Keywords: atrial fibrillation; epidemiology; outcome;Atrial fibrillation; Epidemiology; Outcome
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ISSN: 1099-5129
e-ISSN: 1532-2092
DOI: 10.1093/europace/eut434
ISI #: 000342215100019
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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