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Title: Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children
Authors: De Prins, Sofie
Marcucci, Francesco
Sensi, Laura
Van de Mieroop, Els
Nelen, Vera
Schoeters, Greet
Koppen, Gudrun
Issue Date: 2014
Source: BIOMARKERS, 19 (6), p. 481-487
Abstract: Rhinitis and asthma are the most common respiratory diseases in children. We assessed whether airway inflammation markers were associated with nasal allergies and self-reported symptoms of wheeze and rhinitis in 130 children 6-12 year old in an epidemiological context. Independent of sex and age, the fraction of exhaled nitric oxide (FeNO) and nasal mast cell (MC) activation (tryptase >= 5 ng/mL) were positively associated with wheeze, rhinitis and with nasal allergy. Nasal eosinophil cationic protein (ECP) and exhaled breath condensate (EBC) markers (pH, 8-isoprostane, interleukin-1 beta) were not associated with symptoms or with nasal allergy. In conclusion, FeNO and nasal tryptase reflect allergic inflammation in the respiratory system.
Notes: [De Prins, Sofie; Schoeters, Greet] Vlaamse Instelling Technol Onderzoek, Environm Risk & Hlth Unit, Boeretang, Belgium. [De Prins, Sofie; Schoeters, Greet; Koppen, Gudrun] Univ Antwerp, Fac Pharmaceut Biomed & Vet Sci, B-2020 Antwerp, Belgium. [Marcucci, Francesco; Sensi, Laura] Spin Off ATRP Srl, Allerg Tests Res & Prod Perugia, Perugia, Italy. [Van de Mieroop, Els; Nelen, Vera] Prov Inst Hyg, Environm & Hlth Unit, Antwerp, Belgium. [Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium.
Keywords: Eosinophil cationic protein; exhaled breath condensate; mast cells; Rhinostick;Eosinophil cationic protein; exhaled breath condensate; mast cells; Rhinostick
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ISSN: 1354-750X
e-ISSN: 1366-5804
DOI: 10.3109/1354750X.2014.937362
ISI #: 000340768500007
Category: A1
Type: Journal Contribution
Validations: ecoom 2015
Appears in Collections:Research publications

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