Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/18042
Title: | Is there a correlation between maternal venous hemodynamic dysfunction and proteinuria of preeclampsia? | Authors: | Mesens, Tinne TOMSIN, Kathleen STAELENS, Anneleen OBEN, Jolien MOLENBERGHS, Geert GYSELAERS, Wilfried |
Issue Date: | 2014 | Publisher: | ELSEVIER SCIENCE BV | Source: | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 181, p. 246-250 | Abstract: | Objectives: To evaluate in early and late preeclampsia a correlation of maternal venous Doppler flow characteristics with biochemical parameters in maternal serum and urine, or with gestational outcome. Study design: In this observational cross-sectional study, renal interlobar vein impedance index (RIVI) was measured according to a standardised protocol for combined electrocardiogram-Doppler ultrasonography in 86 women with uncomplicated pregnancy, 78 women with late onset preeclampsia (>= 34 w) and 67 with early onset preeclampsia (<34 w). For each group, maternal age, pre-gestational BMI and parity were recorded together with birth weight and percentile. For both early onset and late onset preeclampsia, maternal serum was analysed for thrombocyte count and concentrations of creatinine, ASAT, ALAT and uric acid and 24 h urine collections were analysed for creatinine clearance and proteinuria (mg/24 h). A non-parametric Mann Whitney U-tests was performed for continuous data and a Fisher's exact tests for categorical data. Significant linear dependence between variables was identified using Pearson's correlation coefficient at nominal level a = 0.05. Results: Proteinuria was higher in early onset than in late onset preeclampsia (1756 mg [838-6116 mg] versus 877 mg [416-1696 mg], p < 0.001), and this was also true for RIVI in both left (0.45 [0.40-0.55] versus 0.41 [0.35-0.45], p = 0.001) and right kidney (0.45 [0.39-0.55] versus 0.38 [0.30-0.43],p < 0.001). In our data set, there was a significant correlation between proteinuria and RIVI of left (correlation coefficient = 0.172, p = 0.036) and right kidney (correlation coefficient = 0.218, p = 0.009) in late onset but not early onset preeclampsia. Conclusion: Maternal RIVI may correlate with proteinuria of late onset preeclampsia. (C) 2014 Elsevier Ireland Ltd. All rights reserved. | Notes: | [Mesens, Tinne; Oben, Jolien; Gyselaers, Wilfried] Ziekenhuis Oost Limburg, Dept Obstet & Gynaecol, Genk, Belgium. [Gyselaers, Wilfried] Hasselt Univ, Dept Physiol, Hasselt, Belgium. [Tomsin, Kathleen; Staelens, Anneleen S.] Hasselt Univ, Dept Med & Life Sci, Hasselt, Belgium. [Molenberghs, Geert] Hasselt Univ, Ctr Med Stat, Hasselt, Belgium. | Keywords: | Pregnancy; proteinuria; venous; Doppler; preeclampsia;pregnancy; proteinuria; venous; Doppler; preeclampsia | Document URI: | http://hdl.handle.net/1942/18042 | ISSN: | 0301-2115 | e-ISSN: | 1872-7654 | DOI: | 10.1016/j.ejogrb.2014.08.008 | ISI #: | 000343952000044 | Rights: | © 2014 Elsevier Ireland Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2015 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
mesens 1.pdf Restricted Access | Published version | 276.45 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
6
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
8
checked on Oct 14, 2024
Page view(s)
70
checked on Sep 7, 2022
Download(s)
44
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.