Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/18787
Title: Sensory innervation around immediately vs. delayed loaded implants: a pilot study
Authors: HUANG, Yanru 
van Dessel, Jeroen
MARTENS, Wendy 
LAMBRICHTS, Ivo 
Zhong, Wei-Jian
Ma, Guowu
LIN, Dan 
LIANG, Xin 
Jacobs, Reinhilde
Issue Date: 2015
Publisher: NATURE PUBLISHING GROUP
Source: INTERNATIONAL JOURNAL OF ORAL SCIENCE, 7 (1), p. 49-55
Abstract: Although neurophysiological and psychophysical proof of osseoperception is accumulating, histomorphometric evidence for the neural mechanisms of functional compensation following immediate and delayed implant loading is still lacking. For this randomized split-mouth study, six mongrel dogs randomly received one of four treatment protocols at 36 implant-recipient sites over 16 weeks (third maxillary incisor, third and fourth mandibular premolar): immediate implant placement and immediate loading (IIP+IL); delayed implant placement and delayed loading (DIP+DL); delayed implant placement and immediate loading (DIP+IL); and natural extraction socket healing (control). Histomorphometry was performed in the pen-implant bone and soft tissues within 300 gm around the implants. Immunocytochemistry and transmission electron microscopy were used to confirm the presence of neural structures and to reveal their ultrastructural characteristics, respectively. Myelinated nerve fibres densely populated the pen-implant crestal gingival and apical regions, although they were also identified in the woven bone and in the osteons near the implant threads. Compared with the control group in the mandible, the group that received IIP+IL showed a higher innervation (in N.mm(-2), 5.94 +/- 1.12 vs. 3.15 +/- 0.63, P<0.001) and smaller fibre diameter (in mu m, 1.37 +/- 0.05 vs. 1.64 +/- 0.13, P=0.016), smaller axon diameter (in mu m, 0.89 +/- 0.05 vs. 1.24 +/- 0.10, P=0.009) and g-ratio (0.64 +/- 0.04 vs. 0.76 +/- 0.05, P<0.001) in the middle region around the implants. Compared with DIP+IL in the mandible, IIP+IL had a higher nerve density (in N.mm(-2), 13.23 +/- 2.54 vs. 9.64 +/- 1.86, P=0.027), greater fibre diameter (in gm, 1.32 +/- 0.02 vs. 1.20 +/- 0.04, P=0.021), greater axon diameter (in gm, 0.92 +/- 0.01 vs. 0.89 +/- 0.03, P=0.035) and lower g-ratio (0.69 +/- 0.01 vs. 0.74 +/- 0.01, P=0.033) in the apical region around the implants. It may be assumed that the treatment protocol with I IP+IL is the preferred method to allow optimized pen-implant re-innervation, but further functional measurements are still required.
Notes: Correspondence: Dr X Liang, School of Stomatology, Dalian Medical University, Dalian 116027, China E-mail: lilyliang13@hotmail.com
Keywords: animal experiments; dental implants; histomorphometry; immediate loading; mechanoreceptor; myelinated nerve fibres; osseoperception;animal experiments; dental implants; histomorphometry; immediate loading; mechanoreceptor; myelinated nerve fibres; osseoperception
Document URI: http://hdl.handle.net/1942/18787
ISSN: 1674-2818
e-ISSN: 2049-3169
DOI: 10.1038/ijos.2014.53
ISI #: 000351189700008
Rights: © 2015 WCSS. All rights reserved. This work is licensed under a Creative Commons AttributionNonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
Category: A1
Type: Journal Contribution
Validations: ecoom 2016
Appears in Collections:Research publications

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