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Title: | A single dose of sodium nitrate does not improve oral glucose tolerance in patients with type 2 diabetes mellitus | Authors: | Cermak, Naomi HANSEN, Dominique Kouw, Imre van Dijk, Jan-Willem Blackwell, Jamie Jones, Andrew Gibala, Martin van Loon, Luc |
Issue Date: | 2015 | Source: | NUTRITION RESEARCH, 35 (8), p. 674-680 | Abstract: | Dietary nitrate supplementation has been proposed as an emerging treatment strategy for type 2 diabetes. We hypothesized that ingestion of a single bolus of dietary nitrate ingestion improves oral glucose tolerance in patients with type 2 diabetes. Seventeen men with type 2 diabetes (HbA1c: 7.3±0.2%) participated in a randomized crossover experiment. Subjects ingested a glucose beverage 2.5 h after consuming either sodium nitrate (0.15 mmol NaNO3-·kg-1) or a placebo solution. Venous blood samples were collected before ingestion of the glucose beverage and every 30 min thereafter during a 2-h period to assess postprandial plasma glucose and insulin concentrations. The results show that plasma nitrate and nitrite levels were increased after sodium nitrate as opposed to placebo ingestion (treatment-effect: P=0.001). Despite the elevated plasma nitrate and nitrite levels, ingestion of sodium nitrate did not attenuate the postprandial rise in plasma glucose and insulin concentrations (time x treatment interaction: P=0.41 for glucose, P=0.93 for insulin). Despite the lack of effect on oral glucose tolerance, basal plasma glucose concentrations measured 2.5 h after sodium nitrate ingestion were lower when compared with the placebo treatment (7.5±0.4 vs 8.3±0.4 mmol/L, respectively; P=0.04). We conclude that ingestion of a single dose of dietary nitrate does not improve subsequent oral glucose tolerance in patients with type 2 diabetes. | Notes: | Correspondence: Luc J.C. van Loon, Ph.D. Faculty of Health, Medicine and Life Sciences Maastricht University P.O. Box 616, 6200 MD Maastricht The Netherlands Tel: +31 43 3881397 Fax: +31 43 3670976 E-mail: L.vanLoon@maastrichtuniversity.nl | Keywords: | cross-over studies; nitrites; nitrates; blood glucose; hyperglycemia; blood glucose; insulin | Document URI: | http://hdl.handle.net/1942/18920 | ISSN: | 0271-5317 | e-ISSN: | 1879-0739 | DOI: | 10.1016/j.nutres.2015.05.017 | ISI #: | 000359512400004 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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cermak et al Nutr Res 2015.pdf | Peer-reviewed author version | 233.15 kB | Adobe PDF | View/Open |
1-s2.0-S0271531715001293-main.pdf Restricted Access | Published version | 391.66 kB | Adobe PDF | View/Open Request a copy |
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