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http://hdl.handle.net/1942/1958
Title: | Seroepidemiology of diphtheria and pertussis in Luxembourg in 2000 | Authors: | Mossong, J Putz, L SHKEDY, Ziv Schneider, F |
Issue Date: | 2006 | Publisher: | CAMBRIDGE UNIV PRESS | Source: | EPIDEMIOLOGY AND INFECTION, 134(3). p. 573-578 | Abstract: | A large serosurvey was carried out in Luxembourg in 2000-2001, to determine the population immunity against a number of vaccine-preventable infections including diphtheria and pertussis. Immunity to diphtheria and pertussis was assessed using an in-house neutralization assay and a commercial ELISA test respectively. Mean pertussis antibody activity decreased from 4 to 8 years of age, reflecting the effects of waning of vaccine-induced immunity. Mean pertussis antibody activity increased during adolescence due to infection in previously vaccinated individuals and levelled out after approximately 20 years of age. For adults > 25 years age, a statistically significant 30% difference in mean antibody activity between men and women was observed. The proportion of seronegatives for diphtheria among children and adolescents aged < 20 years was 2(.)5% reflecting the high vaccination coverage. The proportion seronegative for diphtheria tended to increase with age such that 42% of individuals aged > 40 years were seronegative. Our study supports the recently introduced acellular pertussis vaccine booster at 6 years to reduce pertussis transmission in school-aged children and adolescents. | Notes: | Lab Natl Sante, L-1011 Luxembourg, Luxembourg. CRP Sante, Luxembourg, Luxembourg. Limburgs Univ Ctr, Ctr Stat, Diepenbeek, Belgium.Mossong, J, Lab Natl Sante, POB 1102, L-1011 Luxembourg, Luxembourg.joel.mossong@lns.etat.lu | Document URI: | http://hdl.handle.net/1942/1958 | ISSN: | 0950-2688 | e-ISSN: | 1469-4409 | DOI: | 10.1017/S0950268805005662 | ISI #: | 000237786200018 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2007 |
Appears in Collections: | Research publications |
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