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http://hdl.handle.net/1942/19696
Title: | Differences in the Elemental Isotope Definition May Lead to Errors in Modern Mass-Spectrometry-Based Proteomics | Authors: | CLAESEN, Jurgen Lermyte, Frederik Sobott, Frank BURZYKOWSKI, Tomasz VALKENBORG, Dirk |
Issue Date: | 2015 | Source: | ANALYTICAL CHEMISTRY, 87 (21), 10747-10754 | Abstract: | The elemental isotope definition used to calculate the theoretical masses and isotope distribution of (bio)molecules is considered to be a fixed, universal standard in mass-spectrometrybased proteomics. However, this is an incorrect assumption. In view of the ongoing advances in mass spectrometry technology, and in particular the ever-increasing mass precision, the elemental isotope definition and its variations should be taken into account. We illustrate the effect of the elemental isotope uncertainty on the theoretical and experimental masses with theoretical calculations and examples. | Notes: | Claesen, J (reprint author), Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, B-3590 Diepenbeek, Belgium. jurgen.claesen@uhasselt.be | Document URI: | http://hdl.handle.net/1942/19696 | ISSN: | 0003-2700 | e-ISSN: | 1520-6882 | DOI: | 10.1021/acs.analchem.5b01165 | ISI #: | 000364354900017 | Rights: | © XXXX American Chemical Society | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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acs.analchem.5b01165.pdf Restricted Access | Published version | 1.36 MB | Adobe PDF | View/Open Request a copy |
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