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http://hdl.handle.net/1942/19810
Title: | Glial regulation of the blood-brain barrier in health and disease | Authors: | BROUX, Bieke Gowing, Elizabeth Prat, Alexandre |
Issue Date: | 2015 | Publisher: | SPRINGER HEIDELBERG | Source: | SEMINARS IN IMMUNOPATHOLOGY, 37 (6), p. 577-590 | Abstract: | The brain is the organ with the highest metabolic demand in the body. Therefore, it needs specialized vasculature to provide it with the necessary oxygen and nutrients, while protecting it against pathogens and toxins. The blood-brain barrier (BBB) is very tightly regulated by specialized endothelial cells, two basement membranes, and astrocytic endfeet. The proximity of astrocytes to the vessel makes them perfect candidates to influence the function of the BBB. Moreover, other glial cells are also known to contribute to either BBB quiescence or breakdown. In this review, we summarize the knowledge on glial regulation of the BBB during development, in homeostatic conditions in the adult, and during neuroinflammatory responses. | Notes: | [Broux, Bieke; Gowing, Elizabeth; Prat, Alexandre] Univ Montreal CRCHUM, Ctr Hosp, Ctr Rech, Neuroimmunol Unit, Montreal, PQ H2X 0A9, Canada. [Broux, Bieke; Gowing, Elizabeth; Prat, Alexandre] Univ Montreal, Fac Med, Dept Neurosci, Montreal, PQ H3C 3J7, Canada. [Broux, Bieke] Hasselt Univ, Biomed Res Inst, B-3590 Diepenbeek, Belgium. [Broux, Bieke] Transnatl Univ Limburg, Sch Life Sci, B-3590 Diepenbeek, Belgium. | Keywords: | blood-brain barrier; central nervous system; development; astrocytes; microglia; endothelial cells; neuroinflammation; multiple sclerosis;Blood-brain barrier; Central nervous system; Development; Astrocytes; Microglia; Endothelial cells; Neuroinflammation; Multiple sclerosis | Document URI: | http://hdl.handle.net/1942/19810 | ISSN: | 1863-2297 | e-ISSN: | 1863-2300 | DOI: | 10.1007/s00281-015-0516-2 | ISI #: | 000363271700002 | Rights: | © Springer-Verlag Berlin Heidelberg 2015 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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