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Title: | Evaluation of theophylline imprinted polypyrrole film | Authors: | Baleviciute, Ieva Ratautaite, Vilma Ramanaviciene, Almira Balevicius, Zigmas BROEDERS, Jeroen CROUX, Dieter MCDONALD, Matthew VAHIDPOUR, Farnoosh THOELEN, Ronald DE CEUNINCK, Ward HAENEN, Ken NESLADEK, Milos Reza, Alfonsas Ramanavicius, Arunas |
Issue Date: | 2015 | Publisher: | ELSEVIER SCIENCE SA | Source: | SYNTHETIC METALS, 209, p. 206-211 | Abstract: | In this study some affinity and dielectric properties of molecularly imprinted (MIP) conducting polymer-polypyrrole (Ppy) based thin films were evaluated. Films of polypyrrole molecularly imprinted with theophylline (MIP-Ppy) and non-imprinted polypyrrole (NIP-Ppy) were formed on boron doped silicon (Si) substrates in order to evaluate the efficiency of Ppy to bind theophylline. The substrates were modified with boron-doped oxygen terminated nanocrystalline diamond (B:NCD:O) The dielectric properties of B:NCD:O/Ppy-based multi-layered structures were analyzed using spectroscopic ellipsometry and spectrophotometric techniques. Electrochemical impedance spectroscopy was applied for the investigation of kinetics of theophylline interaction with MIP-Ppy and NIP-Ppy. The sensitivity of molecularly imprinted and non-imprinted polymer films was analyzed by injection of different theophylline concentrations. Assuming that Ppy film electrical capacitance change is a result of Ppy dielectric constant change induced by absorbed theophylline molecules, the electrical capacitance change (Delta C) kinetics at different concentrations of theophylline was analyzed using first pseudo order kinetic equation. The dissociation equilibrium constant K-D of MIP-Ppy/theophylline complex at room temperature was calculated as 1.7 x 10(-8) M, and Gibbs free energy change (Delta G) of MIP-Ppy/theophylline complex formation was calculated as -43.5 kJ/mol. It was concluded that molecularly imprinted polypyrrole thin film could be used for the detection of theophylline. (c) 2015 Elsevier B.V. All rights reserved. | Notes: | [Baleviciute, Ieva; Ratautaite, Vilma; Ramanavicius, Arunas] Vilnius State Univ, Fac Chem, Dept Phys Chem, Vilnius, Lithuania. [Balevicius, Zigmas] State Res Inst, Ctr Phys Sci & Technol, Lab BionanoTechnol, Vilnius, Lithuania. [Ramanaviciene, Almira] Vilnius State Univ, Fac Chem, NanoTechnas Ctr Nanotechnol & Mat Sci, Vilnius, Lithuania. [Broeders, Jeroen; Croux, Dieter; McDonald, Matthew; Vahidpour, Farnoosh; Thoelen, Ronald; De Ceuninck, Ward; Haenen, Ken] Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium. [Thoelen, Ronald; Nesladek, Milos] Res Inst IMEC Vzw, Res Ctr IMOMEC, B-3590 Diepenbeek, Belgium. [De Ceuninck, Ward] Xios Univ Coll, B-3590 Diepenbeek, Belgium. [Reza, Alfonsas] State Res Inst, Dept Optoelect, Ctr Phys Sci & Technol, Vilnius, Lithuania. | Keywords: | Molecular imprints; Molecularly imprinted polymers; Polypyrrole; Theophylline; Ellipsometry;molecular imprints; molecularly imprinted polymers; polypyrrole; theophylline; ellipsometry | Document URI: | http://hdl.handle.net/1942/19847 | ISSN: | 0379-6779 | e-ISSN: | 0379-6779 | DOI: | 10.1016/j.synthmet.2015.07.021 | ISI #: | 000364245900031 | Rights: | © 2015 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2016 |
Appears in Collections: | Research publications |
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