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Title: | Behavioral testing of antidepressant compounds: An analysis of crossover design for correlated binary data | Authors: | SHKEDY, Ziv VANDERSMISSEN, Veerle MOLENBERGHS, Geert Van Craenendonck, H Aerts, Nancy Steckler, T BIJNENS, Luc |
Issue Date: | 2005 | Publisher: | AKADEMIE VERLAG GMBH | Source: | BIOMETRICAL JOURNAL, 47(3). p. 286-298 | Abstract: | The differential reinforcement of low-rate 72 seconds schedule (DRL-72) is a standard behavioral test procedure for screening potential antidepressant compounds. The protocol for the DRL-72 experiment, proposed by Evenden et al. (1993), consists of using a crossover design for the experiment and one-way ANOVA for the statistical analysis. In this paper we discuss the choice of several crossover designs for the DRL-72 experiment and propose to estimate the treatment effects using either generalized linear mixed models (GLMM) or generalized estimating equation (GEE) models for clustered binary data. | Notes: | Limburgs Univ Ctr, Ctr Stat, B-3590 Diepenbeek, Belgium. J&JPRD, Non Clin Biostat, Beerse, Belgium.Shkedy, Z, Limburgs Univ Ctr, Ctr Stat, Univ Campus,Bldg D, B-3590 Diepenbeek, Belgium.ziv.shkedy@luc.ac.be | Keywords: | correlated binary data; crossover design; generalized linear mixed models; generalized estimating equation; odds ratio;correlated binary data; crossover design; generalized linear mixed models; generalized estimating equation; odds ratio | Document URI: | http://hdl.handle.net/1942/2042 | ISSN: | 0323-3847 | e-ISSN: | 1521-4036 | DOI: | 10.1002/bimj.200410130 | ISI #: | 000230361800008 | Rights: | (C) 2005 WILEY-VCH Verlag & Co. KgaA, Weinheim | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2006 |
Appears in Collections: | Research publications |
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