Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2042
Title: Behavioral testing of antidepressant compounds: An analysis of crossover design for correlated binary data
Authors: SHKEDY, Ziv 
VANDERSMISSEN, Veerle 
MOLENBERGHS, Geert 
Van Craenendonck, H
Aerts, Nancy
Steckler, T
BIJNENS, Luc 
Issue Date: 2005
Publisher: AKADEMIE VERLAG GMBH
Source: BIOMETRICAL JOURNAL, 47(3). p. 286-298
Abstract: The differential reinforcement of low-rate 72 seconds schedule (DRL-72) is a standard behavioral test procedure for screening potential antidepressant compounds. The protocol for the DRL-72 experiment, proposed by Evenden et al. (1993), consists of using a crossover design for the experiment and one-way ANOVA for the statistical analysis. In this paper we discuss the choice of several crossover designs for the DRL-72 experiment and propose to estimate the treatment effects using either generalized linear mixed models (GLMM) or generalized estimating equation (GEE) models for clustered binary data.
Notes: Limburgs Univ Ctr, Ctr Stat, B-3590 Diepenbeek, Belgium. J&JPRD, Non Clin Biostat, Beerse, Belgium.Shkedy, Z, Limburgs Univ Ctr, Ctr Stat, Univ Campus,Bldg D, B-3590 Diepenbeek, Belgium.ziv.shkedy@luc.ac.be
Keywords: correlated binary data; crossover design; generalized linear mixed models; generalized estimating equation; odds ratio;correlated binary data; crossover design; generalized linear mixed models; generalized estimating equation; odds ratio
Document URI: http://hdl.handle.net/1942/2042
ISSN: 0323-3847
e-ISSN: 1521-4036
DOI: 10.1002/bimj.200410130
ISI #: 000230361800008
Rights: (C) 2005 WILEY-VCH Verlag & Co. KgaA, Weinheim
Category: A1
Type: Journal Contribution
Validations: ecoom 2006
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
Shkedy_et_al-2005-Biometrical_Journal.pdf
  Restricted Access
Published version139.42 kBAdobe PDFView/Open    Request a copy
Show full item record

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.