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http://hdl.handle.net/1942/2043| Title: | Design and analysis of drug combination experiments | Authors: | STRAETEMANS, Roel O'BRIEN, Timothy WOUTERS, Luc Van Dun, J Janicot, M BIJNENS, Luc BURZYKOWSKI, Tomasz AERTS, Marc |
Issue Date: | 2005 | Publisher: | AKADEMIE VERLAG GMBH | Source: | BIOMETRICAL JOURNAL, 47(3). p. 299-308 | Abstract: | In this paper we present and discuss a novel, simple and easy to implement parametric modeling approach to assess synergy. An extended three parameter log-logistic model is used to analyse the data and calculate confidence intervals of the interaction indices. In addition the model corrects for the bias due to plate-location effects. The analysis is performed with PROC NLMIXED and SAS-code is provided. The approach is illustrated using data coming from an oncology study in which the inhibition effect of a combination of two compounds is studied using 96-well plates and a fixed-ratio design. | Notes: | Limburgs Univ Ctr, Ctr Stat, B-3590 Diepenbeek, Belgium. Loyola Univ, Chicago, IL 60611 USA. Barrier Therapeut, Geel, Belgium. Johnson & Johnson Pharmaceut Res & Dev, Beerse, Belgium.Straetemans, R, Limburgs Univ Ctr, Ctr Stat, Univ Campus, B-3590 Diepenbeek, Belgium.Roel.Straetemans@luc.ac.be | Keywords: | 96-well plates; antagonism; interaction index; drug combination; drug interaction; fixed-ratio design; Hill model; ray design; synergy; pharmacology; plate-location effects | Document URI: | http://hdl.handle.net/1942/2043 | ISSN: | 0323-3847 | e-ISSN: | 1521-4036 | DOI: | 10.1002/bimj.200410124 | ISI #: | 000230361800009 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2006 |
| Appears in Collections: | Research publications |
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