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Title: Occular blood flow in Glaucoma — the Leuven Eye Study
Authors: Pinto, Luís Abegão
Willekens, Koen
Van Keer, Karel
Shibesh, Abraham
Vandewalle, Evelien
Stalmans, Ingeborg
Issue Date: 2016
Source: ACTA OPHTHALMOLOGICA, 94(6), p. 593-599
Abstract: Purpose Elevated intra-ocular pressure (IOP) has been identified as a major risk factor for glaucoma. Additionally, extensive literature depicts a vascular dysfunction to exist in these patients. However, a large ocular blood flow-oriented trial to integrate these findings in the clinical setting is lacking. This study would likely help to identify which of these vascular data can be used as a clinical tool for screening and disease stratification. Method Prospective, cross-sectional, case–control hospital-based study. Patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), glaucoma suspects and healthy volunteers were recruited. In addition to a comprehensive ophthalmological examination, a vascular-oriented questionnaire was completed and ocular blood flow assessment (colour Doppler imaging of retrobulbar vessels, retinal oximetry, dynamic contour tonometry, optical coherent tomography enhanced-depth imaging of the choroid) were performed. Statistical analysis was based on multiple imputation to account for missingness. Results A total of 614 subjects (291 males) were recruited between March and December 2013 (POAG: 214, NTG: 192; OHT: 27; glaucoma suspect: 41; healthy controls: 140). Glaucoma groups (NTG and POAG) were age and gender matched with the control group (p > 0.05). Glaucoma groups were paired in terms of functional and structural parameters (p > 0.08). Mean ocular perfusion pressure was higher in the glaucoma groups than in controls (p < 0.001). Glaucoma groups had lower retrobulbar velocities, higher retinal venous saturation and choroidal thickness asymmetries when compared to the healthy group, in line with the current literature. Conclusions The Leuven Eye Study stands as one of the largest clinical trials on ocular blood flow in glaucoma. The creation of this vast database may help integrate the vascular aspects of glaucoma into the clinical practice of glaucoma.
Notes: Correspondence: Ingeborg Stalmans, MD, PhD Department of Ophthalmology University Hospitals Leuven, Campus St Raphaël Kapucijnenvoer 33 B-3000 Leuven, Belgium Tel: +32 16 33.23.72 Fax: +32 16 33.23.67 Email:
Keywords: colour Doppler imaging; normal-tension glaucoma; ocular blood flow; primary open-angle glaucoma; retinal oximetry
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ISSN: 1755-375X
e-ISSN: 1755-3768
DOI: 10.1111/aos.12962
ISI #: 000383520800039
Rights: © 2016 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd
Category: A1
Type: Journal Contribution
Validations: ecoom 2017
Appears in Collections:Research publications

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