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http://hdl.handle.net/1942/2115| Title: | Pharmacological comparison of two different insect models using the scorpion alpha-like toxin BmK M1 from Buthus martensii Karsch | Authors: | Bosmans, F BRONE, Bert Sun, YM Zhu, RH Xiong, YM Wang, DC VAN KERKHOVE, Emmy Tytgat, J |
Issue Date: | 2005 | Publisher: | BENTHAM SCIENCE PUBL LTD | Source: | PROTEIN AND PEPTIDE LETTERS, 12(4). p. 363-367 | Abstract: | In this study, the effect of the scorpion α-like toxin BmK M I was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na+ channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding α-like toxins. Moreover, with the aid of the α-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown. | Notes: | Katholieke Univ Leuven, Toxicol Lab, B-3000 Louvain, Belgium. Limburgs Univ Ctr, Biomed, Ctr Milieukunde, B-3590 Diepenbeek, Belgium. Chinese Acad Sci, Inst Biophys, Ctr Mol Biol, Beijing 100101, Peoples R China.Tytgat, J, Katholieke Univ Leuven, Toxicol Lab, E Van Evenstr 4, B-3000 Louvain, Belgium.Jan.Tytgat@pharm.kuleuven.ac.be | Keywords: | BmKM1; voltage-gated Na+ channels; locust DUM neurons; para/tipE | Document URI: | http://hdl.handle.net/1942/2115 | ISSN: | 0929-8665 | e-ISSN: | 1875-5305 | DOI: | 10.2174/0929866053765635 | ISI #: | 000229162900011 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2006 |
| Appears in Collections: | Research publications |
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