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Title: | Changes in structural and metabolic muscle characteristics following exercise-based interventions in patients with COPD: a systematic review | Authors: | DE BRANDT, Jana SPRUIT, Martijn A. Derave, Wim HANSEN, Dominique Vanfleteren, Lowie BURTIN, Chris |
Issue Date: | 2016 | Source: | Expert Review of Respiratory Medicine, 10 (5), p. 521-545 | Abstract: | Patients with COPD suffer from lower-limb muscle dysfunction characterized by lower muscle oxidative capacity and muscle mass. Exercise-based training is expected to attenuate lower-limb intramuscular characteristics, but a detailed systematic approach to review the available evidence has not been performed yet. PUBMED and PEDro databases were searched. Twenty-five studies that implemented an exercise-based training program (aerobic and/or resistance training, high intensity interval training, electrical or magnetic stimulation) and reported muscle biopsy data of patients with COPD were critically appraised. The coverage of results includes changes in muscle structure, muscle protein turnover regulation, mitochondrial enzyme activity, oxidative and nitrosative stress, and inflammation after exercise-based training interventions. Study design and training modalities varied among studies, which partly explains the observed heterogeneous response in muscle characteristics. Gaps in the current knowledge are identified and recommendations for future research are made to enhance our knowledge on exercise training effects in patients with COPD. | Notes: | De Brandt, J (reprint author), Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, REVAL Rehabil Res Ctr, Diepenbeek, Belgium jana.debrandt@uhasselt.be | Keywords: | COPD; exercise training; pulmonary rehabilitation; muscle biopsy; vastus lateralis; quadriceps muscle; skeletal muscle; muscle morphology | Document URI: | http://hdl.handle.net/1942/21483 | ISSN: | 1747-6348 | e-ISSN: | 1747-6356 | DOI: | 10.1586/17476348.2016.1157472 | ISI #: | 000374778100006 | Rights: | © 2016 Informa UK Limited, trading as Taylor & Francis Group | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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De Brandt 2016 ERRM.pdf Restricted Access | Published version | 1.96 MB | Adobe PDF | View/Open Request a copy |
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