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http://hdl.handle.net/1942/21556
Title: | Interleukin-25 is detrimental for recovery after spinal cord injury in mice | Authors: | DOOLEY, Dearbhaile LEMMENS, Evi Ponsaerts, Peter HENDRIX, Sven |
Issue Date: | 2016 | Publisher: | BIOMED CENTRAL LTD | Source: | JOURNAL OF NEUROINFLAMMATION, 13 | Abstract: | Background: The cytokine, interleukin (IL)-25, is thought to be critically involved in inducing a type 2 immune response which may contribute to regeneration after central nervous system (CNS) trauma. We investigated whether applying recombinant IL-25, locally or systemically, in a mouse model of spinal cord injury (SCI) improves functional and histological recovery. Findings: Repeated systemic administration of IL-25 did not influence functional recovery following SCI. In contrast, a single local administration of IL-25 significantly worsened locomotor outcome, which was evident from a decreased Basso mouse scale (BMS) score compared with phosphate-buffered saline (PBS)-treated controls. This was accompanied by a significant increase in lesion size, demyelination, and T helper cell infiltration. Conclusions: These data show for the first time that IL-25 is either ineffective when applied systemically or detrimental to spinal cord recovery when applied locally. Our findings question the potential neuroprotective role of IL-25 following CNS trauma. | Notes: | [Dooley, Dearbhaile; Lemmens, Evi; Hendrix, Sven] Hasselt Univ, Biomed Res Inst, Dept Morphol, Diepenbeek, Belgium. [Dooley, Dearbhaile; Ponsaerts, Peter] Univ Antwerp, Vaccine & Infect Dis Inst Vaxinfectio, Lab Expt Hematol, B-2020 Antwerp, Belgium. | Keywords: | IL-25; Type 2 immune response; Spinal cord injury; Basso mouse scale; Locomotor recovery; Th1; Th2;IL-25; Type 2 immune response; spinal cord injury; basso mouse scale; locomotor recovery, Th1, Th2 | Document URI: | http://hdl.handle.net/1942/21556 | e-ISSN: | 1742-2094 | DOI: | 10.1186/s12974-016-0566-y | ISI #: | 000375900000001 | Rights: | © 2016 Dooley et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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dooley 1.pdf | Published version | 1.32 MB | Adobe PDF | View/Open |
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