Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/21773
Title: | High Intensity Aerobic and Resistance Exercise Can Improve Glucose Tolerance in Persons With Multiple Sclerosis: A Randomized Controlled Trial. | Authors: | WENS, Inez Dalgas, Ulrik VANDENABEELE, Frank VERBOVEN, Kenneth HANSEN, Dominique Deckx, Nathalie Cools, Nathalie OP 'T EIJNDE, Bert |
Issue Date: | 2016 | Source: | AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 96 (3), pag. 161-166 | Status: | In press | Abstract: | Introduction: The prevalence of impaired glucose tolerance (IGT) is higher in persons with multiple sclerosis (MS) compared to healthy controls, indicating metabolic deficits that may increase comorbidity. In other populations, IGT can, at least partly, be reversed by intense physical exercise, but this is never investigated before in MS. Aim: To investigate the effect of high intensity aerobic and resistance training on glucose tolerance and skeletal muscle GLUT4 content in MS. Methods: Thirty-four persons with MS (aged 45 T 3 years, EDSS 2.5 T 1.07) were randomized into three groups, including a (1) sedentary control group (SED, n = 11), (2) 12-week high intensity interval plus resistance training group (HITR, n = 12), or (3) 12-week high intensity continuous aerobic training plus resistance training group (HCTR, n = 11). Before and after 12 weeks, glucose tolerance and skeletal muscle GLUT4 content were determined by an oral glucose tolerance test and analysis of a m.vastus lateralis biopsy, respectively. Results: There were no significant changes for subjects of SED. From pre- to post-intervention, total area under the glucose curve (tAUC) decreased significantly in both HITR (j6.9 T 6.2%) and HCTR (j11.0 T 7.7%) (P G 0.05). Insulin tAUC decreased (j12.3 T 14.7%) within HCTR and muscle GLUT4 content increased (+6.6 T 4.5%) in HITR. Conclusion: Twelve weeks of high intensity aerobic exercise in combination with resistance training improved glucose tolerance in persons with MS. | Notes: | Wens, I (reprint author), Hasselt Univ, Fac Med & Life Sci, REVAL Rehabil Res Ctr, BIOMED Biomed Res Inst, Agoralaan Bldg A, B-3590 Diepenbeek, Belgium. | Keywords: | multiple sclerosis; glucose tolerance; high intensity exercise; skeletal muscle; glucose transporter 4 | Document URI: | http://hdl.handle.net/1942/21773 | ISSN: | 0894-9115 | e-ISSN: | 1537-7385 | DOI: | 10.1097/PHM.0000000000000563 | ISI #: | 000395005100010 | Rights: | Copyright © 2016 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Wens et al Am J Phys med Rehabil 2016.pdf Restricted Access | Published version | 677.22 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
14
checked on Sep 7, 2020
WEB OF SCIENCETM
Citations
26
checked on Oct 13, 2024
Page view(s)
20
checked on Sep 7, 2022
Download(s)
8
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.