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Title: | Metabolic targets of endocrine disrupting chemicals assessed by cord blood transcriptome profiling | Authors: | Remy, Sylvie Govarts, Eva Wens, Britt DE BOEVER, Patrick Den Hond, Elly Croes, Kim Sioen, Isabelle Baeyens, Willy van Larebeke, Nicolas Koppe, Janna Covaci, Adrian Schettgen, Thomas Nelen, Vera Legler, Juliette Schoeters, Greet |
Issue Date: | 2016 | Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | Source: | REPRODUCTIVE TOXICOLOGY, 65, p. 307-320 | Abstract: | Early life exposure to endocrine disrupting chemicals (EDCs) has been frequently associated with impaired perinatal growth, an important risk factor for later onset of metabolic disorders. We analyzed whether the cord blood transcriptome showed early indications of alterations in metabolic processes in 195 human samples in relation to cord blood levels of dichlorodiphenyldichloroethylene (p,p'-DDE), polychlorinated biphenyl-153 (PCB-153), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS). Overall, 39 metabolically relevant transcription factors were significantly enriched (31 by p,p'-DDE, 10 by PCB-153, 8 by PFOA, and 2 by PFOS). These included the glucocorticoid receptor (p,p'-DDE and PCB-153) and the progesterone receptor (PFOA and PFOS). The 'insulin receptor signaling', 'acute phase response signaling', 'Interleukin(IL)-6 signaling', and 'prolactin signaling' pathways were significantly enriched in relation to p,p'-DDE. Transcriptional changes at birth suggest a role for specific metabolic targets as a link between prenatal EDC exposure and metabolic disorders later in life. (C) 2016 Elsevier Inc. All rights reserved. | Notes: | [Remy, Sylvie] Univ Antwerp, Epidemiol & Social Med, Univ Pl 1, B-2610 Antwerp, Belgium. [Remy, Sylvie; Govarts, Eva; Wens, Britt; De Boever, Patrick; Den Hond, Elly; Schoeters, Greet] Flemish Inst Technol Res VITO, Environm Risk & Hlth, Boeretang 200, B-2400 Mol, Belgium. [De Boever, Patrick] Hasselt Univ, Ctr Environm Sci, Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium. [Den Hond, Elly] Sci Inst Publ Hlth, Directorate Publ Hlth & Surveillance, Juliette Wytsmanstr 14, B-1050 Brussels, Belgium. [Croes, Kim; Baeyens, Willy; van Larebeke, Nicolas] Vrije Univ Brussel, Dept Analyt Environm & Geochem AEGC, Pl Laan 2, B-1050 Brussels, Belgium. [Sioen, Isabelle] Univ Ghent, Dept Publ Hlth, St Pietersnieuwstr 33, B-9000 Ghent, Belgium. [Sioen, Isabelle] FWO Res Fdn, Egmontstr 5, B-1000 Brussels, Belgium. [van Larebeke, Nicolas] Univ Ghent, Dept Radiotherapy & Expt Canc Res, St Pietersnieuwstr 33, B-9000 Ghent, Belgium. [Koppe, Janna] Univ Amsterdam, EKZ AMC, De Boelelaan 1105, NL-1081 HV Amsterdam, Netherlands. [Covaci, Adrian] Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium. [Schettgen, Thomas] Rhein Westfal TH Aachen, Fac Med, Inst Occupat & Social Med, Pauwelsstr 30, D-52074 Aachen, Germany. [Nelen, Vera] Prov Inst Hyg, Dept Hlth, Kronenburgstr 45, B-2000 Antwerp, Belgium. [Legler, Juliette] Vrije Univ Amsterdam, Inst Environm Studies, De Boelelaan 1105, NL-1081 HV Amsterdam, Netherlands. [Schoeters, Greet] Univ Antwerp, Biomed Sci, Univ Pl 1, B-2610 Antwerp, Belgium. [Schoeters, Greet] Univ Southern Denmark, Environm Med, Campusvej 55, DK-5000 Odense, Denmark. | Keywords: | Birth cohort; Transcriptomics; Cord blood; Endocrine disrupting chemicals; Metabolic disorders; Glucocorticoid receptor;birth cohort; transcriptomics; cord blood; endocrine disrupting chemicals; metabolic disorders; glucocorticoid receptor | Document URI: | http://hdl.handle.net/1942/22750 | ISSN: | 0890-6238 | e-ISSN: | 1873-1708 | DOI: | 10.1016/j.reprotox.2016.08.018 | ISI #: | 000385990900034 | Rights: | © 2016 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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