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Title: | Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth | Authors: | STEVENS, An-Sofie PIROTTE, Nicky WOUTERS, Annelies VAN ROTEN, Andromeda VAN BELLEGHEM, Frank WILLEMS, Maxime CUYPERS, Ann ARTOIS, Tom SMEETS, Karen |
Issue Date: | 2016 | Publisher: | BENTHAM SCIENCE PUBL LTD | Source: | CURRENT DRUG TARGETS, 17(12), p. 1414-1437 | Abstract: | A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneration-competent tissues and animals are able to prevent and counteract growth abnormalities and seem to have a low vulnerability to chemical carcinogenesis. Cancer cell survival depends, among other things, on various redox-related mechanisms, which are targets of currently developed therapies. Disadvantages of these therapies are a lack of specificity and drug resistance. As the majority of these redox-related mechanisms also play an important role in successful and coordinated cell functioning and reproduction, the regeneration process offers a unique parallel context for modern cancer research. This review focuses on the interconnections between regeneration and carcinogenesis and how an understanding of regenerative forces and redox-controlled mechanisms could contribute to the identification of new therapeutic targets to block the growth and survival of cancer cells. | Notes: | [Stevens, An-Sofie; Pirotte, Nicky; Wouters, Annelies; Van Roten, Andromeda; Van Belleghem, Frank; Cuypers, Ann; Artois, Tom; Smeets, Karen] Hasselt Univ, Ctr Environm Sci, Agoralaan,Bldg D, B-3590 Diepenbeek, Belgium. [Van Belleghem, Frank] Open Univ, Fac Management Sci & Technol, Valkenburgweg 177, Heerlen, Netherlands;. [Willems, Maxime] Univ Ghent, Fac Pharmaceut Sci, Lab Pharmaceut Technol, B-9000 Ghent, Belgium. [Willems, Maxime] Univ Ghent, Lab Environm Toxicol & Aquat Ecol, Jozef Plateaustr 22, B-9000 Ghent, Belgium. | Keywords: | anticarcinogenic therapies; carcinogenesis; redox-related mechanisms; regeneration; stem cells;Anticarcinogenic therapies; carcinogenesis; redox-related mechanisms; regeneration; stem cells | Document URI: | http://hdl.handle.net/1942/22847 | ISSN: | 1389-4501 | e-ISSN: | 1873-5592 | DOI: | 10.2174/1389450116666150506112817 | ISI #: | 000387082600006 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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Redoxrelatedmechanisms.pdf | Peer-reviewed author version | 883.96 kB | Adobe PDF | View/Open |
Stevens(2016).pdf Restricted Access | Published version | 12.52 MB | Adobe PDF | View/Open Request a copy |
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