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|Title:||Prevalence and incidence of neurological disorders among adult Ugandans in rural and urban Mukono district; a cross-sectional study||Authors:||Kaddumukasa, Mark
Kaddumukasa, Martin N.
|Issue Date:||2016||Publisher:||BIOMED CENTRAL LTD||Source:||BMC NEUROLOGY, 16 (Art N° 227)||Abstract:||Background: The burden of neurological diseases is increasing in developing countries. However, there is a prominent scarcity of literature on the incidence of neurological diseases in sub-Saharan Africa. This study was therefore undertaken to determine the prevalence and incidence of neurological diseases in this setting to serve as a baseline for planning and care for neurological disorders in Uganda. Methods: The study was conducted within rural and urban Mukono district, east of Kampala city of Uganda, central region. Over a period of six months, a cross sectional survey was conducted and screening was performed using a standardized questionnaire. All subjects with neurological symptoms and signs were reviewed by a team of neurologists and neurological diagnoses made. Results: Of the 3000 study subjects, 50.3% (1510/3000) were from the rural setting. Out of the participants screened, 67.4% were female, with a median age of 33 years. Among the 98 subjects with confirmed neurological disorders, the frequency of diseases was as follows; peripheral neuropathy (46.2%), chronic headaches (26.4%), and epilepsy (8.5%), followed by pain syndromes (7.5%), stroke (6.6%) and tremors/Parkinson disease (3.8%). The crude prevalence rates of these disorders (95% CI) were 14.3% (8.5-24.1); 13.3% (7.7-22.8); 33.7% (23.9-47.4) for stroke, epilepsy and peripheral neuropathy respectively. Peripheral neuropathy followed by chronic headaches had the highest estimated incidence/1000 years. Stroke had an estimated incidence of 3.6 new cases with 95% CI of (2.1-6.1)/1000 years. Conclusion: Peripheral neuropathy, chronic headaches and epilepsy disorders are major causes of morbidity in Sub-Saharan settings. There is an urgent need of more robust and powered studies to determine the incidence of these diseases.||Notes:||[Kaddumukasa, Mark; Kaddumukasa, Martin N.; Katabira, Elly] Makerere Univ, Coll Hlth Sci, Sch Med, Dept Med, POB 7072, Kampala, Uganda. [Mugenyi, Leviticus] Infect Dis Res Collaborat, Mulago Hill Rd,MUJHU3 Bldg,POB 7475, Kampala, Uganda. [Mugenyi, Leviticus] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Ddumba, Edward] Nkozi Univ, St Raphael St Francis Nsambya Hosp, Dept Med, POB 7146, Kampala, Uganda. [Devereaux, Michael; Furlan, Anthony] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Neurol Inst, 11100 Euclid Ave, Cleveland, OH 44106 USA. [Sajatovic, Martha] Univ Hosp Case Med Ctr, Neurol & Behav Outcomes Ctr, 11100 Euclid Ave, Cleveland, OH 44106 USA.||Keywords:||Epidemiology; Neurological disorders; Prevalence; Uganda;epidemiology; neurological disorders; prevalence, Uganda||Document URI:||http://hdl.handle.net/1942/23037||e-ISSN:||1471-2377||DOI:||10.1186/s12883-016-0732-y||ISI #:||000388129600005||Rights:||© The Author(s). 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.||Category:||A1||Type:||Journal Contribution||Validations:||ecoom 2017|
|Appears in Collections:||Research publications|
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