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http://hdl.handle.net/1942/23077
Title: | Profluorescent PPV-based Micellar System as a Versatile Probe for Bioimaging and Drug Delivery | Authors: | ZAQUEN, Neomy Lu, Hongxu Chang, Teddy Mamdooh, Russel LUTSEN, Laurence VANDERZANDE, Dirk Stenzel, Martina JUNKERS, Tanja |
Issue Date: | 2016 | Publisher: | AMER CHEMICAL SOC | Source: | Biomacromolecules, 17(12), p. 4086-4094 | Abstract: | Although micelles are commonly used for drug delivery purposes, their long-term fate is often unknown due to photobleaching of the fluorescent labels or the use of toxic materials. Here, we present a metal-free, nontoxic, nonbleaching, fluorescent micelle that can address these shortcomings. A simple, yet versatile, profluorescent micellar system, built from amphiphilic poly(p-phenylenevinylene) (PPV) block copolymers, for use in drug delivery applications is introduced. Polymer micelles made from PPV show excellent stability for up to 1 year and are successfully loaded with anticancer drugs (curcumin or doxorubicin) without requiring introduction of physical or chemical cross-links. The micelles are taken up efficiently by the cells, which triggers disassembly, releasing the encapsulated material. Disassembly of the micelles and drug release is conveniently monitored as fluorescence of the single polymer chains appear, which enables not only to monitor the release of the payload, but in principle also the fate of the polymer over longer periods of time. | Keywords: | Antineoplastic Agents;Cell Survival;Curcumin;Doxorubicin;Drug Carriers;Fluorescent Dyes;Humans;Molecular Imaging;Pancreatic Neoplasms;Polymers;Polyvinyls;Tumor Cells, Cultured;Drug Delivery Systems;Micelles | Document URI: | http://hdl.handle.net/1942/23077 | ISSN: | 1525-7797 | e-ISSN: | 1526-4602 | DOI: | 10.1021/acs.biomac.6b01653 | ISI #: | 000389787200026 | Rights: | 2016 American Chemical Society | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Zaquen et at SI.pdf Restricted Access | Supplementary material | 2.4 MB | Adobe PDF | View/Open Request a copy |
preprint.pdf Restricted Access | Non Peer-reviewed author version | 1.72 MB | Adobe PDF | View/Open Request a copy |
Profluorescent PPV-Based Micellar System as a Versatile Probe for Bioimaging and Drug Delivery.pdf Restricted Access | Published version | 5.19 MB | Adobe PDF | View/Open Request a copy |
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