Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23077
Title: Profluorescent PPV-based Micellar System as a Versatile Probe for Bioimaging and Drug Delivery
Authors: ZAQUEN, Neomy 
Lu, Hongxu
Chang, Teddy
Mamdooh, Russel
LUTSEN, Laurence 
VANDERZANDE, Dirk 
Stenzel, Martina
JUNKERS, Tanja 
Issue Date: 2016
Publisher: AMER CHEMICAL SOC
Source: Biomacromolecules, 17(12), p. 4086-4094
Abstract: Although micelles are commonly used for drug delivery purposes, their long-term fate is often unknown due to photobleaching of the fluorescent labels or the use of toxic materials. Here, we present a metal-free, nontoxic, nonbleaching, fluorescent micelle that can address these shortcomings. A simple, yet versatile, profluorescent micellar system, built from amphiphilic poly(p-phenylenevinylene) (PPV) block copolymers, for use in drug delivery applications is introduced. Polymer micelles made from PPV show excellent stability for up to 1 year and are successfully loaded with anticancer drugs (curcumin or doxorubicin) without requiring introduction of physical or chemical cross-links. The micelles are taken up efficiently by the cells, which triggers disassembly, releasing the encapsulated material. Disassembly of the micelles and drug release is conveniently monitored as fluorescence of the single polymer chains appear, which enables not only to monitor the release of the payload, but in principle also the fate of the polymer over longer periods of time.
Keywords: Antineoplastic Agents;Cell Survival;Curcumin;Doxorubicin;Drug Carriers;Fluorescent Dyes;Humans;Molecular Imaging;Pancreatic Neoplasms;Polymers;Polyvinyls;Tumor Cells, Cultured;Drug Delivery Systems;Micelles
Document URI: http://hdl.handle.net/1942/23077
ISSN: 1525-7797
e-ISSN: 1526-4602
DOI: 10.1021/acs.biomac.6b01653
ISI #: 000389787200026
Rights: 2016 American Chemical Society
Category: A1
Type: Journal Contribution
Validations: ecoom 2018
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
Zaquen et at SI.pdf
  Restricted Access
Supplementary material2.4 MBAdobe PDFView/Open    Request a copy
preprint.pdf
  Restricted Access
Non Peer-reviewed author version1.72 MBAdobe PDFView/Open    Request a copy
Profluorescent PPV-Based Micellar System as a Versatile Probe for Bioimaging and Drug Delivery.pdf
  Restricted Access
Published version5.19 MBAdobe PDFView/Open    Request a copy
Show full item record

SCOPUSTM   
Citations

14
checked on Sep 3, 2020

WEB OF SCIENCETM
Citations

26
checked on Mar 29, 2024

Page view(s)

80
checked on Jun 13, 2022

Download(s)

44
checked on Jun 13, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.