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Title: | B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses | Authors: | FRAUSSEN, Judith CLAES, Nele VAN WIJMEERSCH, Bart VAN HORSSEN, Jack STINISSEN, Piet Hupperts, Raymond SOMERS, Veerle |
Issue Date: | 2016 | Publisher: | ACADEMIC PRESS INC ELSEVIER SCIENCE | Source: | CLINICAL IMMUNOLOGY, 173, p. 124-132 | Abstract: | Antibody-independent B cell functions play an important role in multiple sclerosis (MS) pathogenesis. In this study, B cell antigen presentation and costimulation in MS were studied. Peripheral blood B cells of MS patients showed increased expression of costimulatory CD86 and CD80 molecules compared with healthy controls (HC). In MS cerebrospinal fluid (CSF), 12-fold and 2-fold increases in CD86(+) and CD80 B cells, respectively, were evidenced compared with peripheral blood. Further, B cells from MS patients induced proinflammatory T cells in response to myelin basic protein (MBP). Immunomodulatory treatment restored B cell costimulatory molecule expression and caused significantly reduced B cell induced T cell responses. Together, these results demonstrate the potential of B cells from MS patients to induce autoreactive proinflammatory T cell responses. Immunomodulatory therapy abrogated this effect, emphasizing the importance of B cell antigen presentation and costimulation in MS pathology. (C) 2016 Elsevier Inc. All rights reserved. | Notes: | [Fraussen, Judith; Claes, Nele; Van Wijmeersch, Bart; van Horssen, Jack; Stinissen, Piet; Somers, Veerle] Univ Limburg, Hasselt Univ, Sch Life Sci, Biomed Res Inst & Transnat, Diepenbeek, Belgium. [Van Wijmeersch, Bart] Revalidat & MS Ctr, Overpelt, Belgium. [van Horssen, Jack] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands. [Hupperts, Raymond] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Neurosci, Maastricht, Netherlands. [Hupperts, Raymond] Acad MS Ctr Limburg, Zuyderland Med Centrum, Sittard, Netherlands. | Keywords: | multiple sclerosis; B cells; antigen presentation; costimulatory molecules; T cells;Multiple sclerosis; B cells; Antigen presentation; Costimulatory molecules; T cells | Document URI: | http://hdl.handle.net/1942/23270 | ISSN: | 1521-6616 | e-ISSN: | 1521-7035 | DOI: | 10.1016/j.clim.2016.10.001 | ISI #: | 000389864200017 | Rights: | © 2016 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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faussen 1.pdf Restricted Access | Published version | 1.15 MB | Adobe PDF | View/Open Request a copy |
Fraussen J et al Clin Immunol author version.pdf | Peer-reviewed author version | 629.57 kB | Adobe PDF | View/Open |
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