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Title: | Inflammation at the blood-brain barrier: The role of liver X receptors | Authors: | de Wit, Nienke VANMOL, Jasmine Kamermans, A. HENDRIKS, Jerome de Vries, Elga |
Issue Date: | 2016 | Publisher: | ACADEMIC PRESS INC ELSEVIER SCIENCE | Source: | Neurobiology of disease, 107, pag. 57-65 | Abstract: | The blood-brain barrier (BBB) is indispensable for the maintenance of brain homeostasis and proper neuronal functioning. Dysfunction of the BBB significantly contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases like stroke, multiple sclerosis (MS), and Alzheimer's disease (AD). The neuroinflammatory environment that characterizes these disorders propagates chronic impaired function of the BBB, processes that will be discussed in this review. Limiting dysfunction of the BBB may be an attractive target for treatment of neurological disorders. To date, no current treatments are directly targeting the function of the BBB. In this review, we will specifically discuss the potential protective role of nuclear liver X receptors (LXRs) as a promising therapeutic target to reverse or prevent BBB impairment in neurological diseases. | Notes: | de Wit, NM (reprint author), Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, Neurosci Campus Amsterdam, POB 7057, NL-1007 MB Amsterdam, Netherlands. n.dewit1@vumc.nl | Keywords: | Liver X receptor;Blood-brain barrier;Neuroinflammation;Neurodegenerative disease;Tight junction | Document URI: | http://hdl.handle.net/1942/23308 | ISSN: | 0969-9961 | e-ISSN: | 1095-953X | DOI: | 10.1016/j.nbd.2016.09.015 | ISI #: | 000411169900006 | Rights: | © 2016 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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Inflammation at the blood-brain barrier AV.pdf | Peer-reviewed author version | 893 kB | Adobe PDF | View/Open |
Inflammation at the blood-brain barrier_ The role of liver X receptors _ Elsevier Enhanced Reader.pdf Restricted Access | Published version | 8.46 MB | Adobe PDF | View/Open Request a copy |
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