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http://hdl.handle.net/1942/23641
Title: | Importance of Abnormal Chloride Homeostasis in Stable Chronic Heart Failure | Authors: | Grodin, Justin L. VERBRUGGE, Frederik Ellis, Stephen G. MULLENS, Wilfried Testani, Jeffrey M. Tang, W. H. Wilson |
Issue Date: | 2016 | Source: | CIRCULATION-HEART FAILURE, 9(1) (Art N° e002453) | Abstract: | Background—The aim of this analysis was to determine the long-term prognostic value of lower serum chloride in patients with stable chronic heart failure. Electrolyte abnormalities are prevalent in patients with chronic heart failure. Little is known regarding the prognostic implications of lower serum chloride. Methods and Results—Serum chloride was measured in 1673 consecutively consented stable patients with a history of heart failure undergoing elective diagnostic coronary angiography. All patients were followed for 5-year all-cause mortality, and survival models were adjusted for variables that confounded the chloride–risk relationship. The average chloride level was 102±4 mEq/L. Over 6772 person-years of follow-up, there were 547 deaths. Lower chloride (per standard deviation decrease) was associated with a higher adjusted risk of mortality (hazard ratio 1.29, 95% confidence interval 1.12–1.49; P | Keywords: | chloride; electrolyte imbalances; heart failure; sodium | Document URI: | http://hdl.handle.net/1942/23641 | ISSN: | 1941-3289 | e-ISSN: | 1941-3297 | DOI: | 10.1161/CIRCHEARTFAILURE.115.002453 | ISI #: | 000368620100001 | Rights: | © 2015 American Heart Association, Inc | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2017 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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e002453.full.pdf Restricted Access | Published version | 1.1 MB | Adobe PDF | View/Open Request a copy |
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