Novel design for the thermal based biosensor using the transient plane source(TPS) technique

Abstract

In an urge to fulfill the increasing demand for reliable economical biosensor readout techniques, researchers at IMO-IMOMEC developed the Heat-Transfer Method. With this method it is possible to perform bioanalytical tasks by closely monitoring heat transfer trough a detection layer. The original sensor design uses thermocouples and a separate resistive heater. In order to miniaturize and optimize the HTM setup, a new sensor design based on the transient plane source(TPS) technique was proposed. The transient plane source technique has been accepted as an ISO standard (ISO/DIS 220072.2). The TPS technique allows in plane sensing and heating. The heat transfer method is a label free method and the samples do not require pretreatment or extra reagents.