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Title: | Predictive value of different covariates influencing pregnancy rate following intrauterine insemination with homologous semen: a prospective cohort study | Authors: | THIJSSEN, Annelies CREEMERS, An VAN DER ELST, Wim Creemers, Eva Vandormael, Eva Dhont, Nathalie OMBELET, Willem |
Issue Date: | 2017 | Publisher: | ELSEVIER SCI LTD | Source: | REPRODUCTIVE BIOMEDICINE ONLINE, 34(5), p. 463-472 | Abstract: | The aim was to examine the value of different covariates in the prediction of intrauterine insemination (IUI) success. Between July 2011 and September 2015, data from 1401 IUI cycles with homologous semen in 556 couples were collected prospectively, by questionnaire, in a tertiary referral infertility centre. Statistical analysis was performed using generalized estimating equations (GEEs). GEEs were used instead of an ordinary logistic regression model to take into account the correlation between observations from the same person. The primary outcome parameter was clinical pregnancy rate (CPR), confirmed with a gestational sac and fetal heartbeat on ultrasonography at 7-8 weeks. An overall CPR of 9.5% per cycle was observed. Uni-variate statistical analysis revealed female and male age, male smoking, female body mass index, ovarian stimulation and inseminating motile count (IMC) as covariates significantly influencing CPR per cycle. Multivariate GEE analysis revealed that the only valuable prognostic covariates included female age, male smoking and infertility status (i.e. primary/secondary infertility). IMC showed a significant curvilinear relationship, with first an increase and then a decrease in pregnancy rate. (C) 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. | Notes: | [Thijssen, Annelies; Creemers, Eva; Vandormael, Eva; Dhont, Nathalie; Ombelet, Willem] Genk Inst Fertil Technol, Ziekenhuis Oost Limburg, Dept Obstet & Gynecol, Schiepse Bos 6, B-3600 Genk, Belgium. [Thijssen, Annelies; Ombelet, Willem] Hasselt Univ, Dept Physiol, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Creemers, An; Van der Elst, Wim] Hasselt Univ, Ctr Stat CENSTAT, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. | Keywords: | Homologous semen; Intrauterine insemination; Prognostic factor; Prospective cohort study; Success rate;homologous semen; intrauterine insemination; prognostic factor; prospective cohort study; success rate | Document URI: | http://hdl.handle.net/1942/24229 | ISSN: | 1472-6483 | e-ISSN: | 1472-6491 | DOI: | 10.1016/j.rbmo.2017.01.016 | ISI #: | 000401128200004 | Rights: | © 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2018 |
Appears in Collections: | Research publications |
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